Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 352772..353454 Replicon chromosome
Accession NZ_CP069943
Organism Klebsiella oxytoca strain FDAARGOS_1332

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag I6K62_RS01580 Protein ID WP_064360218.1
Coordinates 352772..353092 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag I6K62_RS01585 Protein ID WP_064360219.1
Coordinates 353113..353454 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K62_RS01555 348380..349084 + 705 WP_032726119.1 DNA/RNA non-specific endonuclease -
I6K62_RS01560 349373..349696 + 324 WP_023320260.1 endoribonuclease SymE -
I6K62_RS01565 349843..350277 + 435 WP_023320259.1 VOC family protein -
I6K62_RS01570 350443..351186 + 744 WP_204724738.1 hypothetical protein -
I6K62_RS01575 351532..352665 + 1134 WP_064360217.1 hypothetical protein -
I6K62_RS01580 352772..353092 - 321 WP_064360218.1 TA system toxin CbtA family protein Toxin
I6K62_RS01585 353113..353454 - 342 WP_064360219.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6K62_RS01590 353465..354004 - 540 WP_064360220.1 DNA repair protein RadC -
I6K62_RS01595 354017..354457 - 441 WP_064360221.1 antirestriction protein -
I6K62_RS01600 354488..355309 - 822 WP_064360222.1 DUF945 domain-containing protein -
I6K62_RS01605 355429..355902 - 474 WP_064360223.1 hypothetical protein -
I6K62_RS01610 355974..356426 - 453 WP_000734321.1 hypothetical protein -
I6K62_RS01615 356462..357178 - 717 WP_012543038.1 WYL domain-containing protein -
I6K62_RS01620 357422..358297 - 876 WP_064360224.1 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 349843..390184 40341


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-102)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12024.91 Da        Isoelectric Point: 7.1633

>T192207 WP_064360218.1 NZ_CP069943:c353092-352772 [Klebsiella oxytoca]
MKTLPAINPQAATLCLSPVAVWQKLLARLLEQHYGLTLNDTPFSDETVILEHIYAGISLADAVNFLVEKYELVRIDRRGF
NWREQSPYLQVVDILRVRQAIGSSSK

Download         Length: 321 bp

>T192207 NZ_CP092184:c1387140-1386847 [Serratia marcescens]
ATGGGAACTCTAAAACTACGTAAATGGGATAGCGCCGAGCACCTCAACAGTGATGAGGACATCGTTGCCTATCTGGAAGC
CTGCATGGAAGAAGCCGGTGACGATGCAGCTTTCATTGCCAAGGCATTGGGAAACATCGCCCGCGCTCGCGGCATGACTC
AACTCGCCAAGGAAACAGGCGTAGGCCGCGAAAGCCTATACAAAGCGTTGTCAGGAGAGGGTAACCCGAGTTTCGGCACA
ATCCTGAAAGTCATGCATGCTCTCGGGTTACGCCTACACACTACGGCTGCCTGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12873.37 Da        Isoelectric Point: 5.4865

>AT192207 WP_064360219.1 NZ_CP069943:c353454-353113 [Klebsiella oxytoca]
MKSTDSENDSFLQWGLNRNVTPCFGARLVQEGNRLHYLVDRASITGEFSNAESLKLDEVFPHFISQMESMLTTGELNPRH
AHCFTLYHNGFTCEADTLGSYGYVYIAIYPTQR

Download         Length: 342 bp

>AT192207 NZ_CP092184:c1387440-1387150 [Serratia marcescens]
ATGAAGATTATTTATACCACCGAAGAGTTCGACAGCTGGTTTACCGGCCTTCGCGACAGGCAAGCCCAGAAGCGCATTCA
GACCCGTATCGACCGTGCGGAAGGTGGAAATTTTGGCGACTGCGAACCTGTTGGCGAAGGCGTGTCAGAAATGCGAATTC
ATTACGGCCCCGGCTATCGAGTGTATTTCGTGCAGCAAGGCATGGAGATTGTGATTTTGCTAGCCGGTGGCGATAAGTCC
ACCCAATCCAAAGATATTAAAGCTGCGCTTGAACTCGCGCGACAGCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References