Detailed information of TA system TA192207

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 352772..353454
• Replicon: chromosome
• Accession: NZ_CP069943
• Organism: Klebsiella oxytoca strain FDAARGOS_1332

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: I6K62_RS01580
• Protein ID: WP_064360218.1
• Coordinates: 352772..353092 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: I6K62_RS01585
• Protein ID: WP_064360219.1
• Coordinates: 353113..353454 (-)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K62_RS01555	348380..349084	+	705	WP_032726119.1	DNA/RNA non-specific endonuclease	-
I6K62_RS01560	349373..349696	+	324	WP_023320260.1	endoribonuclease SymE	-
I6K62_RS01565	349843..350277	+	435	WP_023320259.1	VOC family protein	-
I6K62_RS01570	350443..351186	+	744	WP_204724738.1	hypothetical protein	-
I6K62_RS01575	351532..352665	+	1134	WP_064360217.1	hypothetical protein	-
I6K62_RS01580	352772..353092	-	321	WP_064360218.1	TA system toxin CbtA family protein	Toxin
I6K62_RS01585	353113..353454	-	342	WP_064360219.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
I6K62_RS01590	353465..354004	-	540	WP_064360220.1	DNA repair protein RadC	-
I6K62_RS01595	354017..354457	-	441	WP_064360221.1	antirestriction protein	-
I6K62_RS01600	354488..355309	-	822	WP_064360222.1	DUF945 domain-containing protein	-
I6K62_RS01605	355429..355902	-	474	WP_064360223.1	hypothetical protein	-
I6K62_RS01610	355974..356426	-	453	WP_000734321.1	hypothetical protein	-
I6K62_RS01615	356462..357178	-	717	WP_012543038.1	WYL domain-containing protein	-
I6K62_RS01620	357422..358297	-	876	WP_064360224.1	GTPase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	349843..390184	40341

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-102)

Antitoxin

• Antitoxin CbeA (13-112)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12024.91 Da
• Isoelectric Point: 7.1633

>T192207 WP_064360218.1 NZ_CP069943:c353092-352772 [Klebsiella oxytoca]
MKTLPAINPQAATLCLSPVAVWQKLLARLLEQHYGLTLNDTPFSDETVILEHIYAGISLADAVNFLVEKYELVRIDRRGF
NWREQSPYLQVVDILRVRQAIGSSSK

Nucleotide

• Length: 321 bp

>T192207 NZ_CP092184:c1387140-1386847 [Serratia marcescens]
ATGGGAACTCTAAAACTACGTAAATGGGATAGCGCCGAGCACCTCAACAGTGATGAGGACATCGTTGCCTATCTGGAAGC
CTGCATGGAAGAAGCCGGTGACGATGCAGCTTTCATTGCCAAGGCATTGGGAAACATCGCCCGCGCTCGCGGCATGACTC
AACTCGCCAAGGAAACAGGCGTAGGCCGCGAAAGCCTATACAAAGCGTTGTCAGGAGAGGGTAACCCGAGTTTCGGCACA
ATCCTGAAAGTCATGCATGCTCTCGGGTTACGCCTACACACTACGGCTGCCTGA

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12873.37 Da
• Isoelectric Point: 5.4865

>AT192207 WP_064360219.1 NZ_CP069943:c353454-353113 [Klebsiella oxytoca]
MKSTDSENDSFLQWGLNRNVTPCFGARLVQEGNRLHYLVDRASITGEFSNAESLKLDEVFPHFISQMESMLTTGELNPRH
AHCFTLYHNGFTCEADTLGSYGYVYIAIYPTQR

Nucleotide

• Length: 342 bp

>AT192207 NZ_CP092184:c1387440-1387150 [Serratia marcescens]
ATGAAGATTATTTATACCACCGAAGAGTTCGACAGCTGGTTTACCGGCCTTCGCGACAGGCAAGCCCAGAAGCGCATTCA
GACCCGTATCGACCGTGCGGAAGGTGGAAATTTTGGCGACTGCGAACCTGTTGGCGAAGGCGTGTCAGAAATGCGAATTC
ATTACGGCCCCGGCTATCGAGTGTATTTCGTGCAGCAAGGCATGGAGATTGTGATTTTGCTAGCCGGTGGCGATAAGTCC
ACCCAATCCAAAGATATTAAAGCTGCGCTTGAACTCGCGCGACAGCTATAG