Detailed information of TA system TA192205

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 141261..142171
• Replicon: plasmid unnamed
• Accession: NZ_CP069941
• Organism: Klebsiella pneumoniae strain FDAARGOS_1312

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A663AYG0
• Locus tag: I6K42_RS26190
• Protein ID: WP_004026354.1
• Coordinates: 141261..141731 (-)
• Length: 157 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A6P1V3Q9
• Locus tag: I6K42_RS26195
• Protein ID: WP_004026357.1
• Coordinates: 141728..142171 (-)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K42_RS26170	136673..137071	-	399	WP_004212796.1	H-NS histone family protein	-
I6K42_RS26175	137408..137902	-	495	WP_004212794.1	thermonuclease family protein	-
I6K42_RS26180	138080..139029	+	950	Protein_147	DUF1173 family protein	-
I6K42_RS26185	140415..141112	-	698	Protein_148	IS1 family transposase	-
I6K42_RS26190	141261..141731	-	471	WP_004026354.1	RES family NAD+ phosphorylase	Toxin
I6K42_RS26195	141728..142171	-	444	WP_004026357.1	DUF2384 domain-containing protein	Antitoxin
I6K42_RS26200	142272..142775	-	504	Protein_151	DUF4113 domain-containing protein	-
I6K42_RS26205	142873..143094	-	222	WP_004213643.1	DUF2188 domain-containing protein	-
I6K42_RS26210	143239..143394	-	156	WP_004213642.1	hypothetical protein	-
I6K42_RS26215	143469..145595	-	2127	WP_004213640.1	TonB-dependent receptor family protein	-
I6K42_RS26220	145682..146635	-	954	Protein_155	fec operon regulator FecR	-
I6K42_RS26225	146632..147153	-	522	WP_004213635.1	sigma-70 family RNA polymerase sigma factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	-	iroB / iroC / iroD / iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA2	1..224781	224781
	-	flank	IS/Tn	-	-	140415..140918	503

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (30-89)

Sequences

Toxin

Protein

• Length: 157 a.a.
• Molecular weight: 17515.79 Da
• Isoelectric Point: 4.6155

>T192205 WP_004026354.1 NZ_CP069941:c141731-141261 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Nucleotide

• Length: 471 bp

>T192205 NZ_CP092184:596211-596552 [Serratia marcescens]
ATGAAAACTCTACCTGCAACAAATCCGCAGGCGGCGACGCTATGTCTGTCACCCGTGGCAGTCTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACACCATTCAGTGATGAAATGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCTGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAGGGGATTC
GACTGGCAAGAACAGTCCCCATATCTGCGGACAGTCGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGAAAAGAAA
TCGTATTAGCGCGGCACGGTGA

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16480.80 Da
• Isoelectric Point: 10.2498

>AT192205 WP_004026357.1 NZ_CP069941:c142171-141728 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Nucleotide

• Length: 444 bp

>AT192205 NZ_CP092184:595849-596190 [Serratia marcescens]
ATGAAATCTACTGATTCAGAGAGCGATTCATTTCTCAAGTGGGGTCTGAATCGTAATGTGACACCTTGCTTTGGTGCTCG
TCTGGTACAGGAGGGAAACCGACTGCACTATTTGGCTGACCGGGCCAGTATCACCGGTAAGTTCAGCGAAGCAGAATGTC
TTAAGCTGGATGCGGCATTCCCGCATTTTATCTGCCAGATGGAATCGATGCTGACTACTGGTGAAATGAATCCTCGCCAT
GCCCACTGTGTCACCCTGTACCACAATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTACGTATACATCGC
CGTTTACCCCACTCATCGTTAA

Structures

Toxin

• AlphaFold DB: A0A663AYG0

Antitoxin

• AlphaFold DB: A0A6P1V3Q9