Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3785059..3785678 Replicon chromosome
Accession NZ_CP069940
Organism Klebsiella pneumoniae strain FDAARGOS_1312

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag I6K42_RS18055 Protein ID WP_002892050.1
Coordinates 3785059..3785277 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag I6K42_RS18060 Protein ID WP_002892066.1
Coordinates 3785304..3785678 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K42_RS18020 3781106..3781369 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
I6K42_RS18025 3781369..3781509 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
I6K42_RS18030 3781506..3782204 - 699 WP_002892021.1 GNAT family N-acetyltransferase -
I6K42_RS18035 3782305..3783756 + 1452 WP_014907971.1 PLP-dependent aminotransferase family protein -
I6K42_RS18040 3783731..3784201 - 471 WP_002892026.1 YlaC family protein -
I6K42_RS18045 3784222..3784362 + 141 WP_004147370.1 hypothetical protein -
I6K42_RS18050 3784334..3784900 - 567 WP_002892030.1 maltose O-acetyltransferase -
I6K42_RS18055 3785059..3785277 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
I6K42_RS18060 3785304..3785678 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
I6K42_RS18065 3786164..3789310 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
I6K42_RS18070 3789333..3790526 - 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T192202 WP_002892050.1 NZ_CP069940:c3785277-3785059 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T192202 NZ_CP092182:c1424880-1424587 [Alcaligenes faecalis]
ATGACCGCCATCAAAACTGCCCCTTTCGACGCCGCTGAATATCTTGATAGTGAGGAATCTATCGCCGAGTACCTCTCTGC
TGCTTTGGAAGAGGACGATCCAGCCTTGTTCCTTTCTGCGCTTGCGGATGTGGTTAAAGCCAGAGGCATGACAAAGATGG
CAAAAGACGCCGGTGTAGGCCGAGAAAGCCTGTACAAGGCCCTGGCTCCCGGTGCCAAGCCACGATATGACACTGTGCTG
AAATTAGCGCGGGCTGCTGGAGTGAAATTAACGGTAGAGCCGCTTCATGCATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT192202 WP_002892066.1 NZ_CP069940:c3785678-3785304 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT192202 NZ_CP092182:c1425103-1424924 [Alcaligenes faecalis]
GTGGTTCGCATTAAACAAGCCAGCCTGGGTAATTTCGGAGACGTAAAGCCAATTAGTGATGGCGTGTCTGAGATGCGCAT
CCACTTCGGCCCGGGCTATCGTCTCTACTATGCTCGTGAGGGCCGTGTGGTCTATCTGCTACTTAGCGGGGGCGACAAGT
CCTCTCAAAACAAGACATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References