Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 3193598..3194408 Replicon chromosome
Accession NZ_CP069940
Organism Klebsiella pneumoniae strain FDAARGOS_1312

Toxin (Protein)


Gene name KacT Uniprot ID A0A332NV98
Locus tag I6K42_RS15210 Protein ID WP_014908042.1
Coordinates 3193875..3194408 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag I6K42_RS15205 Protein ID WP_002887278.1
Coordinates 3193598..3193864 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K42_RS15185 3189470..3189814 - 345 WP_012737331.1 cation efflux system protein CusF -
I6K42_RS15190 3189832..3191217 - 1386 WP_012737332.1 efflux transporter outer membrane subunit -
I6K42_RS15195 3191389..3192072 + 684 WP_002887273.1 copper response regulator transcription factor CusR -
I6K42_RS15200 3192062..3193495 + 1434 WP_204752785.1 Cu(+)/Ag(+) sensor histidine kinase -
I6K42_RS15205 3193598..3193864 + 267 WP_002887278.1 DUF1778 domain-containing protein Antitoxin
I6K42_RS15210 3193875..3194408 + 534 WP_014908042.1 GNAT family N-acetyltransferase Toxin
I6K42_RS15215 3194456..3195577 - 1122 WP_012737335.1 cupin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-150)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19795.68 Da        Isoelectric Point: 5.2614

>T192201 WP_014908042.1 NZ_CP069940:3193875-3194408 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGLGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

>T192201 NZ_CP092182:1381929-1382255 [Alcaligenes faecalis]
TTGAGCAGCTCTGAGCGGCAGCCCACAAAATACAAATTAAAGTTCTTGCCCGAAGCCTTGCAAGAGCGGGGCAGGCTCGA
TGGTAGTGTAAAAACCACCTTTAAGACCTTGCTTCGTAAACGCTTGGATGCACTACGCGTACCGGGGTCCGCCTTGCGGG
GCGATTTGCAGCATTGCTACAAAATCAAACTTCTTAAACAGGGCTATCGTCTGGTTTATACCGTTGAGGATGATGTTCTG
GTGGTATTGGTCTTGGCGGTAAACAAGCGGGAAGACATGGCGGTGTACCGCGTTGCTATTCAGCGCTTAAGTGAGGATTT
GGATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT192201 WP_002887278.1 NZ_CP069940:3193598-3193864 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp

>AT192201 NZ_CP092182:1381691-1381942 [Alcaligenes faecalis]
ATGGATGCGATCTACGCTGATTATTCTATTAGCATGTCCGAGTTCAAGAAGAACCCGGCACAGGTATTGCGTACGGCTGG
AGAAAAGCCTGTTGCTGTGTTGCACCATAACCGGCCTGCCTTTTATATGGTGACTCCTCGTTTGTTCGAGGCTTTGGTCG
AAGAAATGGCTAATCGGGATCTGGATGAGTTGGTGCGTCGACGGCAGGCCGTCAAGGATACGGCGGTCGAGGTTGATCTT
GAGCAGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A332NV98

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References