Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3027979..3028495 Replicon chromosome
Accession NZ_CP069940
Organism Klebsiella pneumoniae strain FDAARGOS_1312

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag I6K42_RS14490 Protein ID WP_004178374.1
Coordinates 3028211..3028495 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag I6K42_RS14485 Protein ID WP_002886901.1
Coordinates 3027979..3028221 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K42_RS14470 3024007..3024747 + 741 WP_002886899.1 KDGP aldolase family protein -
I6K42_RS14475 3024814..3025968 + 1155 WP_012737230.1 lactonase family protein -
I6K42_RS14480 3025991..3027901 + 1911 WP_012737231.1 BglG family transcription antiterminator -
I6K42_RS14485 3027979..3028221 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I6K42_RS14490 3028211..3028495 + 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6K42_RS14495 3028499..3028963 - 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
I6K42_RS14500 3029292..3031430 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
I6K42_RS14505 3031787..3032530 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
I6K42_RS14510 3032533..3032706 - 174 WP_041169004.1 hypothetical protein -
I6K42_RS14515 3032791..3033099 + 309 WP_012737232.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T192200 WP_004178374.1 NZ_CP069940:3028211-3028495 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T192200 NZ_CP092182:c1006114-1005461 [Alcaligenes faecalis]
ATGGCATACGACTACAGCAAAACGCTAAACCCTCAAAAAGCCCTTATTTGGCGTATTGTGCACCGAGACAACATACCGTG
GATCCTTGGGAATAATTTACATTGCGGCAACAGTTCAGCACAAGCCACTAGCTGGGTAACCATCGGTAATACTGAGCTTA
TTGGTAAGCGTGGTGAGCGCGAGGTACCTATAGCCCCAGGTGGTGTTTTGAATGACTATATTCCATTCTATTTCACCCCG
TTCTCACCAATGATGATAAATATTCATAGCGGAAGGGGTGGAGTTCAACGCCGACCCAATGAGGAAATCGTAATTCTTGT
TTCCGACTTGCACCGCATCAGTGCACAAAAAATACCTTTCGTTTATACCGACAAGCATGCTTATTATGGATGGGCTAATT
TTTATACTGACATTCAACACCTTCATAATATTGATTGGAAAATTCTACAAACCAGAGACTTTAGGCGAGATCCTAATGAC
TTAGAGAAGTTTGAACGCTATCAAGCAGAAGCTTTGATTCATCAAATGCTGCCAGTATCCGCATTATTGGGAATGATTTG
CTATACAGACGATACTAAAACCACCATAGAAAGATGGCTTCAAAAGCAGAAAATTAACATACCAGTTCACACTCGACCAG
GATGGTACTTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT192200 WP_002886901.1 NZ_CP069940:3027979-3028221 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT192200 NZ_CP092182:c1005461-1004385 [Alcaligenes faecalis]
ATGATTAACTACACCAAAGGCAATTTACTTACCGCCGATGTTGAGGCGTTAGTCAATACAGTTAATACTGTCGGCGTAAT
GGGAAAAGGTATTGCCCTAATGTTTAAAGAGCGCTTCCCTAAAAACATGGCTGAATATGCACTTGCATGTAAAGAAAACC
GTGTCACAACAGGGAAAATGTTTATCACTAGCACTGGGGAACTGAGCGGCGTAAAGTGGATTGTTAACTTCCCAACTAAG
CAACATTGGCGCGCCAAGTCGAAAATCGAGTGGATAATCGATGGCTTAAAGGATCTACGCCTGTTTATAGAACAGAATGA
CATTAAATCTATCGCTATCCCTCCTCTTGGGGCTGGTAATGGGGGTTTAGATTGGAATGATGTTAAACCCCTTATAGAAA
AAACCCTTGGTGACCTTCAAAACACTGAAATTCAAGTCTATGAACCAACGTCTAAATATCAAAATATCGCCAAAAATACA
GGGGTAAAAAAACTAACGCCAGCAAGAGCAATGATTGCAGAGCTCATCCGCCGATACTGGATTCTTGGCATGGAATGCAG
CCTGCTTGAAATTCAAAAACTATCCTGGTTCCTGCAGCGCGTTATCGAAGTTAACAATTTAAAAAATGAGCTCAATTTAA
GATTTCAAGCCAAAAACTATGGCCCTTATGCTAGTAATTTGGGGCATCTATTAAATGCGCTTGATGGAAGCTACCTATCC
TCTGACAAAAGGATTCCTGACTGCGACCCACTTGATGTCATAGCTTTCAATGACCCACAAAAAGAATATATACAAGCCTA
CCTTGCAAGTGAAGGAAAAATTTATTTACCTGCAATAGAAAAAGCAAGCGAAATAATCAACGGATTTGAATCACCTTTTG
GTATGGAGCTACTGTCTACTGTTGACTGGTTACTTAGCACGGGAAGTAGTGAACCATCTCTTGATTCGATTAAAGAAGGC
ATAAAAAACTGGCCTGCGGGTGAACGATGGGCTCAGCGAAAACTAGTCATTTTCAATGATGAAAGCTTAAGCCTTGCTTT
AAAACATATTATTTCAATTAATTTTCGATACAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References