Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2285214..2285730 Replicon chromosome
Accession NZ_CP069939
Organism Klebsiella pneumoniae strain FDAARGOS_1318

Toxin (Protein)


Gene name relE Uniprot ID A0A486Q7B5
Locus tag I6K48_RS11145 Protein ID WP_004192395.1
Coordinates 2285214..2285498 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A483GCT9
Locus tag I6K48_RS11150 Protein ID WP_004192397.1
Coordinates 2285488..2285730 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K48_RS11120 2280631..2280939 - 309 WP_004192389.1 PTS sugar transporter subunit IIB -
I6K48_RS11125 2281024..2281197 + 174 WP_002886906.1 hypothetical protein -
I6K48_RS11130 2281200..2281943 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
I6K48_RS11135 2282300..2284438 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
I6K48_RS11140 2284746..2285210 + 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
I6K48_RS11145 2285214..2285498 - 285 WP_004192395.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6K48_RS11150 2285488..2285730 - 243 WP_004192397.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I6K48_RS11155 2285808..2287718 - 1911 WP_004152270.1 BglG family transcription antiterminator -
I6K48_RS11160 2287741..2288895 - 1155 WP_004178372.1 lactonase family protein -
I6K48_RS11165 2288962..2289702 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11184.03 Da        Isoelectric Point: 10.3787

>T192173 WP_004192395.1 NZ_CP069939:c2285498-2285214 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQVNKRL

Download         Length: 285 bp

>T192173 NZ_CP092121:c4618010-4617636 [Klebsiella quasipneumoniae subsp. similipneumoniae]
ATGCAAAAACAATCCCTGTCCTCTCATAGGGCGGCCTCGTCACGTCTGTCATCAATCGAAATCTGGCGAAAATTACTGAA
GTATCTGCTGGAGCAACACTACGGCCTTACCCTCAACGACACACCGTTTGGCAACGACAGTGTGATCCAGAAGCACATTG
ATGCGGGAATCTCACTGTGTGATGCGGTGAATTTTATCGTGGAAAAGTACGACCTGGTGCGTACTGACCGTCACGGCTTC
AGCGTGAAAGAGCAGTCTCCGTTTATCGGCAGCATTGATATGCTCCGCGCCCGGAAGGCTACCGGGCTGATGACCCGCAA
GGGATATAAAACCGTTACTGACATCACAGGTGACAGATTCAGCGGAGGGAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9073.60 Da        Isoelectric Point: 6.3340

>AT192173 WP_004192397.1 NZ_CP069939:c2285730-2285488 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEVVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT192173 NZ_CP092121:c4618419-4618060 [Klebsiella quasipneumoniae subsp. similipneumoniae]
ATGAAGAAAGCAACCCGTGTAATCAACCATAACATCGCGGAACCCTGGTGGGGCCTCAGACGCAACATCACGCCGTGTTT
GGGTGCCCGGCTGGTACAGGAGGGTAACCGCCTGCATTACCTTGCTGACCGCGCCAGCATTGCCGGGACATTTAATGACG
CAGATTTACGCCATCTGGACCAGGCATTTCCGGTACTGATGAAACAGATGGAGCTTATGCTGGCCAGCAGAGAACTCACG
CCCCACATTCAGCGCTGCATTACGCTCCACGCAAAAGGGCTGATATGTGAGGCCGATACGCTCGGCTCCTGTGGCTATCT
GTACATCGTAATTTATCCGACATCTGCAACAACCGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486Q7B5

Antitoxin

Source ID Structure
AlphaFold DB A0A483GCT9

References