Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3666711..3667512 | Replicon | chromosome |
| Accession | NZ_CP069935 | ||
| Organism | Escherichia coli strain FDAARGOS_1302 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A0E0XS49 |
| Locus tag | I6K32_RS17865 | Protein ID | WP_001094437.1 |
| Coordinates | 3667135..3667512 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A0E0XTQ1 |
| Locus tag | I6K32_RS17860 | Protein ID | WP_001390338.1 |
| Coordinates | 3666711..3667088 (+) | Length | 126 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6K32_RS17835 (3663826) | 3663826..3664021 | + | 196 | Protein_3526 | DUF905 family protein | - |
| I6K32_RS17840 (3664139) | 3664139..3664957 | + | 819 | WP_001535681.1 | DUF932 domain-containing protein | - |
| I6K32_RS17845 (3665299) | 3665299..3665772 | + | 474 | WP_000855064.1 | antirestriction protein | - |
| I6K32_RS17850 (3665788) | 3665788..3666264 | + | 477 | WP_001535682.1 | RadC family protein | - |
| I6K32_RS17855 (3666327) | 3666327..3666548 | + | 222 | WP_000692345.1 | DUF987 domain-containing protein | - |
| I6K32_RS17860 (3666711) | 3666711..3667088 | + | 378 | WP_001390338.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| I6K32_RS17865 (3667135) | 3667135..3667512 | + | 378 | WP_001094437.1 | TA system toxin CbtA family protein | Toxin |
| I6K32_RS17870 (3667509) | 3667509..3667997 | + | 489 | WP_000761716.1 | DUF5983 family protein | - |
| I6K32_RS17875 (3668017) | 3668017..3668214 | + | 198 | WP_000772032.1 | DUF957 domain-containing protein | - |
| I6K32_RS17880 (3668299) | 3668299..3669144 | + | 846 | WP_001274561.1 | DUF4942 domain-containing protein | - |
| I6K32_RS17885 (3669737) | 3669737..3670105 | + | 369 | WP_000509809.1 | hypothetical protein | - |
| I6K32_RS17890 (3670402) | 3670402..3671325 | + | 924 | WP_001351210.1 | carboxylate/amino acid/amine transporter | - |
| I6K32_RS17895 (3671329) | 3671329..3672147 | - | 819 | WP_000779409.1 | lipoprotein NlpA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | blaTEM-1B / sul2 / aph(3'')-Ib / aph(6)-Id | - | 3633633..3670105 | 36472 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13986.90 Da Isoelectric Point: 7.3223
>T192158 WP_001094437.1 NZ_CP069935:3667135-3667512 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
Download Length: 378 bp
>T192158 NZ_CP092106:c2167224-2166907 [Vibrio sp. JC009]
ATGCATGTTATAAGAAGAGAACCATTTGAGACAGCAAAAGCGCTTTACCCTAACTGCGCTGATGCTTTGGATGCAACTTA
TAAGGCTTTAGAAAAATCAACAGCACAGACACCAGAAGAGTTAAAAGGATTATTTCCCTCTCTGGATAACTTTAAGTATG
TACCTAAATGGTATGTGATAGATATAGGCGGGAACTCACTGAGGCTTATTGCCTTTATTGAGTTTCATGGTAGCAAGTGC
TTTGTAAAACACATTGTTACTCATGCAGAATATGATCGTATAACAGAAGGTTACAGGTCGAAAAAGATAAAGAGGTAA
ATGCATGTTATAAGAAGAGAACCATTTGAGACAGCAAAAGCGCTTTACCCTAACTGCGCTGATGCTTTGGATGCAACTTA
TAAGGCTTTAGAAAAATCAACAGCACAGACACCAGAAGAGTTAAAAGGATTATTTCCCTCTCTGGATAACTTTAAGTATG
TACCTAAATGGTATGTGATAGATATAGGCGGGAACTCACTGAGGCTTATTGCCTTTATTGAGTTTCATGGTAGCAAGTGC
TTTGTAAAACACATTGTTACTCATGCAGAATATGATCGTATAACAGAAGGTTACAGGTCGAAAAAGATAAAGAGGTAA
Antitoxin
Download Length: 126 a.a. Molecular weight: 13745.44 Da Isoelectric Point: 5.0463
>AT192158 WP_001390338.1 NZ_CP069935:3666711-3667088 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTITLYAKGLTCEADTLGSCGYAYLAVYPTPAEPAITV
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTITLYAKGLTCEADTLGSCGYAYLAVYPTPAEPAITV
Download Length: 378 bp
>AT192158 NZ_CP092106:c2166903-2166484 [Vibrio sp. JC009]
ATGATAAATATTCAAGATTTACAGCAAACAGTACAGCAGATAGAAAAAAACATGCCTTGGCTAAGAGGCATTTCTAATCA
GGCAGAATATGAACAACTGATTGAGCTAATGAACGAATTGGTTGAGGACTATGACGCAAATCAGACTCTGATTGACCTGA
TGTTTCCGGTTATTCATGAATATGAGTCTAAGTCTGAACAGTTTAGTGAATTTAACAAAGCCATCAGTGAGCTAAATTCT
GGTGTTGCAGTTTTACGGGTTATTATTGACCAATACAACTTAACTTTAAGCGATTTTCAAAATGAGATTGGTGCTAAGTC
AACGGTATCAATGATACTGAGCGGTAAACGTTCCCTGACCTTGGCGCATATCAGGGCTTTGTCGGAGCGCTTTAATATAC
CGCCCCAAATGTTTATTTAA
ATGATAAATATTCAAGATTTACAGCAAACAGTACAGCAGATAGAAAAAAACATGCCTTGGCTAAGAGGCATTTCTAATCA
GGCAGAATATGAACAACTGATTGAGCTAATGAACGAATTGGTTGAGGACTATGACGCAAATCAGACTCTGATTGACCTGA
TGTTTCCGGTTATTCATGAATATGAGTCTAAGTCTGAACAGTTTAGTGAATTTAACAAAGCCATCAGTGAGCTAAATTCT
GGTGTTGCAGTTTTACGGGTTATTATTGACCAATACAACTTAACTTTAAGCGATTTTCAAAATGAGATTGGTGCTAAGTC
AACGGTATCAATGATACTGAGCGGTAAACGTTCCCTGACCTTGGCGCATATCAGGGCTTTGTCGGAGCGCTTTAATATAC
CGCCCCAAATGTTTATTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0XS49 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0XTQ1 |