Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/PRK09907-MazE |
Location | 2578331..2578914 | Replicon | chromosome |
Accession | NZ_CP069935 | ||
Organism | Escherichia coli strain FDAARGOS_1302 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | V0SV58 |
Locus tag | I6K32_RS12690 | Protein ID | WP_000254750.1 |
Coordinates | 2578331..2578666 (-) | Length | 112 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | S1P3W5 |
Locus tag | I6K32_RS12695 | Protein ID | WP_000581937.1 |
Coordinates | 2578666..2578914 (-) | Length | 83 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
I6K32_RS12675 (2574217) | 2574217..2575515 | - | 1299 | WP_000036723.1 | phosphopyruvate hydratase | - |
I6K32_RS12680 (2575603) | 2575603..2577240 | - | 1638 | WP_000210878.1 | CTP synthase (glutamine hydrolyzing) | - |
I6K32_RS12685 (2577468) | 2577468..2578259 | - | 792 | WP_001071648.1 | nucleoside triphosphate pyrophosphohydrolase | - |
I6K32_RS12690 (2578331) | 2578331..2578666 | - | 336 | WP_000254750.1 | endoribonuclease MazF | Toxin |
I6K32_RS12695 (2578666) | 2578666..2578914 | - | 249 | WP_000581937.1 | type II toxin-antitoxin system antitoxin MazE | Antitoxin |
I6K32_RS12700 (2578992) | 2578992..2581226 | - | 2235 | WP_000226815.1 | GTP pyrophosphokinase | - |
I6K32_RS12705 (2581274) | 2581274..2582575 | - | 1302 | WP_000046816.1 | 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 112 a.a. Molecular weight: 12067.95 Da Isoelectric Point: 8.2618
>T192149 WP_000254750.1 NZ_CP069935:c2578666-2578331 [Escherichia coli]
MVSRYVPDTGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG
MVSRYVPDTGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG
Download Length: 336 bp
>T192149 NZ_CP092106:233041-233325 [Vibrio sp. JC009]
ATGTATAAACTCTCTCTGCGCGCGGTCAAAGATATTGAAAGTATTTATGAGTATACCCTTCTCAACTTTGGCGAATGCAG
AGCAGACAAATACACAAATGATTTGGAATCATGCCTTGAAATTCTTGCCGAGTCTCCTTTTATTGGTCGTGAATCGAATG
AAATAAGAAAAGGTATCCGCAGACATGACTTCCAGAAGCACTCGATTTTCTATAGAGTCAGGGAGTTAGATGTATTTATA
ATCCGAATCCTTCACCAGCAAATGTACCCCGCCCTCCACTTCTGA
ATGTATAAACTCTCTCTGCGCGCGGTCAAAGATATTGAAAGTATTTATGAGTATACCCTTCTCAACTTTGGCGAATGCAG
AGCAGACAAATACACAAATGATTTGGAATCATGCCTTGAAATTCTTGCCGAGTCTCCTTTTATTGGTCGTGAATCGAATG
AAATAAGAAAAGGTATCCGCAGACATGACTTCCAGAAGCACTCGATTTTCTATAGAGTCAGGGAGTTAGATGTATTTATA
ATCCGAATCCTTCACCAGCAAATGTACCCCGCCCTCCACTTCTGA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9355.74 Da Isoelectric Point: 4.4665
>AT192149 WP_000581937.1 NZ_CP069935:c2578914-2578666 [Escherichia coli]
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW
Download Length: 249 bp
>AT192149 NZ_CP092106:232806-233048 [Vibrio sp. JC009]
ATGGCGAGAACAACAAGCGTGACAATTGGTGAACCTTTAGAAAAGTTTGTAAATCGTATGCTTGAGTCAGGGCGTTATGG
CTCTGCCAGTGAAGTGATGCGGAGTGCACTTCGGTTGCTTGAACAACAAGAAAATCAACTTGAGCATCTAAGAAATGCAA
TAGATGAAGGGGAGCTAAGCGGAGAAAGTACTTTATCTGTTAAAGAGATTGTCGCAAAGAAAAAGGCTTCAATGCATGTA
TAA
ATGGCGAGAACAACAAGCGTGACAATTGGTGAACCTTTAGAAAAGTTTGTAAATCGTATGCTTGAGTCAGGGCGTTATGG
CTCTGCCAGTGAAGTGATGCGGAGTGCACTTCGGTTGCTTGAACAACAAGAAAATCAACTTGAGCATCTAAGAAATGCAA
TAGATGAAGGGGAGCTAAGCGGAGAAAGTACTTTATCTGTTAAAGAGATTGTCGCAAAGAAAAAGGCTTCAATGCATGTA
TAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | V0SV58 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9LMB4 |