Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 126412..126937 Replicon plasmid unnamed1
Accession NZ_CP069912
Organism Klebsiella oxytoca strain FDAARGOS_1334

Toxin (Protein)


Gene name ccdB Uniprot ID J5VBT8
Locus tag I6K64_RS28040 Protein ID WP_004197633.1
Coordinates 126632..126937 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A1D8K3R4
Locus tag I6K64_RS28035 Protein ID WP_006788213.1
Coordinates 126412..126630 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K64_RS28015 122314..123591 - 1278 WP_009309915.1 HlyD family secretion protein -
I6K64_RS28020 124253..125131 + 879 WP_009309916.1 restriction endonuclease -
I6K64_RS28025 125172..125588 - 417 WP_032425563.1 type II toxin-antitoxin system VapC family toxin -
I6K64_RS28030 125585..125815 - 231 WP_001261276.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
I6K64_RS28035 126412..126630 + 219 WP_006788213.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
I6K64_RS28040 126632..126937 + 306 WP_004197633.1 type II toxin-antitoxin system toxin CcdB Toxin
I6K64_RS28045 127166..127306 + 141 WP_162898808.1 hypothetical protein -
I6K64_RS28050 127356..127691 + 336 WP_009309920.1 hypothetical protein -
I6K64_RS28055 127725..128741 + 1017 WP_009309921.1 hypothetical protein -
I6K64_RS28060 128939..129718 + 780 WP_023287113.1 site-specific integrase -
I6K64_RS28065 129776..130033 - 258 WP_009310077.1 hypothetical protein -
I6K64_RS28070 130160..131140 + 981 WP_014386491.1 IS5-like element ISKpn26 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..141778 141778


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 13091.77 Da        Isoelectric Point: 12.8043

>T192133 WP_004197633.1 NZ_CP069912:126632-126937 [Klebsiella oxytoca]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Download         Length: 306 bp

>T192133 NZ_CP092077:1886454-1886556 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 9374.72 Da        Isoelectric Point: 12.6573

>AT192133 WP_006788213.1 NZ_CP069912:126412-126630 [Klebsiella oxytoca]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 219 bp

>AT192133 NZ_CP092077:c1886563-1886418 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MCG5

Antitoxin

Source ID Structure
AlphaFold DB A0A1D8K3R4

References