Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 125172..125815 Replicon plasmid unnamed1
Accession NZ_CP069912
Organism Klebsiella oxytoca strain FDAARGOS_1334

Toxin (Protein)


Gene name vagD Uniprot ID A0A7D6UII7
Locus tag I6K64_RS28025 Protein ID WP_032425563.1
Coordinates 125172..125588 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag I6K64_RS28030 Protein ID WP_001261276.1
Coordinates 125585..125815 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K64_RS28010 120216..122324 - 2109 WP_204724553.1 ATP-binding cassette domain-containing protein -
I6K64_RS28015 122314..123591 - 1278 WP_009309915.1 HlyD family secretion protein -
I6K64_RS28020 124253..125131 + 879 WP_009309916.1 restriction endonuclease -
I6K64_RS28025 125172..125588 - 417 WP_032425563.1 type II toxin-antitoxin system VapC family toxin Toxin
I6K64_RS28030 125585..125815 - 231 WP_001261276.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
I6K64_RS28035 126412..126630 + 219 WP_006788213.1 type II toxin-antitoxin system antitoxin CcdA -
I6K64_RS28040 126632..126937 + 306 WP_004197633.1 type II toxin-antitoxin system toxin CcdB -
I6K64_RS28045 127166..127306 + 141 WP_162898808.1 hypothetical protein -
I6K64_RS28050 127356..127691 + 336 WP_009309920.1 hypothetical protein -
I6K64_RS28055 127725..128741 + 1017 WP_009309921.1 hypothetical protein -
I6K64_RS28060 128939..129718 + 780 WP_023287113.1 site-specific integrase -
I6K64_RS28065 129776..130033 - 258 WP_009310077.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..141778 141778


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 20475.56 Da        Isoelectric Point: 5.5500

>T192132 WP_032425563.1 NZ_CP069912:c125588-125172 [Klebsiella oxytoca]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 417 bp

>T192132 NZ_CP092077:797324-797734 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 11350.61 Da        Isoelectric Point: 5.5500

>AT192132 WP_001261276.1 NZ_CP069912:c125815-125585 [Klebsiella oxytoca]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 231 bp

>AT192132 NZ_CP092077:797077-797343 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6UII7

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References