Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 38307..38833 Replicon plasmid unnamed1
Accession NZ_CP069912
Organism Klebsiella oxytoca strain FDAARGOS_1334

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag I6K64_RS27465 Protein ID WP_000323025.1
Coordinates 38546..38833 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID J5W3H0
Locus tag I6K64_RS27460 Protein ID WP_004196370.1
Coordinates 38307..38546 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K64_RS27430 33644..33836 - 193 Protein_38 MFS transporter -
I6K64_RS27435 33866..34843 + 978 WP_004196334.1 chromate resistance protein -
I6K64_RS27440 34800..36176 + 1377 Protein_40 chromate efflux transporter -
I6K64_RS27445 36207..36896 - 690 WP_004196322.1 hypothetical protein -
I6K64_RS27450 36910..37647 - 738 WP_008460272.1 HupE/UreJ family protein -
I6K64_RS27455 37691..38056 - 366 WP_009651956.1 hypothetical protein -
I6K64_RS27460 38307..38546 + 240 WP_004196370.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
I6K64_RS27465 38546..38833 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
I6K64_RS27470 38900..39934 - 1035 Protein_46 IS481 family transposase -
I6K64_RS27475 40006..40164 + 159 WP_014343509.1 type I toxin-antitoxin system Hok family toxin -
I6K64_RS27480 40243..41355 + 1113 WP_001300563.1 IS4-like element IS421 family transposase -
I6K64_RS27485 42211..42483 + 273 WP_032425552.1 hypothetical protein -
I6K64_RS27490 42480..42830 + 351 WP_032425551.1 hypothetical protein -
I6K64_RS27495 42845..43162 + 318 WP_015065519.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..141778 141778


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 12322.73 Da        Isoelectric Point: 12.7777

>T192131 WP_000323025.1 NZ_CP069912:38546-38833 [Klebsiella oxytoca]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKK

Download         Length: 288 bp

>T192131 NZ_CP092077:353871-354218 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAATGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 10271.94 Da        Isoelectric Point: 12.6975

>AT192131 WP_004196370.1 NZ_CP069912:38307-38546 [Klebsiella oxytoca]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 240 bp

>AT192131 NZ_CP092077:354218-354517 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCAGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4QRH4

References