192129

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 5066637..5067256 Replicon chromosome
Accession NZ_CP069907
Organism Klebsiella pneumoniae strain FDAARGOS_1313

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag I6K43_RS27815 Protein ID WP_002892050.1
Coordinates 5066637..5066855 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag I6K43_RS27820 Protein ID WP_002892066.1
Coordinates 5066882..5067256 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K43_RS27780 5062685..5062948 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
I6K43_RS27785 5062948..5063088 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
I6K43_RS27790 5063085..5063783 - 699 WP_002892021.1 GNAT family N-acetyltransferase -
I6K43_RS27795 5063883..5065334 + 1452 WP_009307955.1 PLP-dependent aminotransferase family protein -
I6K43_RS27800 5065309..5065779 - 471 WP_002892026.1 YlaC family protein -
I6K43_RS27805 5065800..5065940 + 141 WP_004147370.1 hypothetical protein -
I6K43_RS27810 5065912..5066478 - 567 WP_002892030.1 maltose O-acetyltransferase -
I6K43_RS27815 5066637..5066855 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
I6K43_RS27820 5066882..5067256 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
I6K43_RS27825 5067742..5070888 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
I6K43_RS27830 5070911..5072104 - 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T192129 WP_002892050.1 NZ_CP069907:c5066855-5066637 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T192129 NZ_CP092076:6840-7100 [Salmonella enterica]
ATGAAGATAAGAAAAGGTGACAGACAATATTATCTGAATAAAGAAGGTGATACGTTTCATCTGGTGAAGCGAGTAAAAAC
TTTTTCTAAGTCTGCGACTTTAGGAAAAACGAAAGCAACGGTGAAAACTGTTGCTGATCTTGTTTTTCATGAGGAGGCAT
TCGACACTATCGACTTTGCCAGCGACGGATTAAGAGAGAATGATAAAGAAATTGTTTCTATGATGATTCAGGAAATGAGT
GAGGGAAAAAATGCCAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT192129 WP_002892066.1 NZ_CP069907:c5067256-5066882 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT192129 NZ_CP092076:7090-7341 [Salmonella enterica]
ATGCCAAATGAAAACACACCAGAAAACATTAAACGTCTGCGGCAAAAAATTGGCCTGACACAGAAAGAATGTGCTGAAAT
ATTCAGCATGAGTCCGCGTACCTGGCGTCGCAAAGAAGAACCTGTCGGAACTGCAAGCGGTACAGCACTTACACCAGTAG
AGTTTAAATTTCTTCTGCTTTTAGCTGGAGAACACCCTGATTATGTACTTTGTAAAAGGAATAAAAAGAATTCTGATTCT
GGAAGTAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References