192125

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 3876959..3877584 Replicon chromosome
Accession NZ_CP069907
Organism Klebsiella pneumoniae strain FDAARGOS_1313

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag I6K43_RS22145 Protein ID WP_002882817.1
Coordinates 3877201..3877584 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag I6K43_RS22140 Protein ID WP_004150355.1
Coordinates 3876959..3877201 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K43_RS22115 3872950..3873549 + 600 WP_004151865.1 glucose-1-phosphatase -
I6K43_RS22120 3873543..3874403 + 861 WP_002882807.1 virulence factor BrkB family protein -
I6K43_RS22125 3874400..3874837 + 438 WP_002882809.1 D-tyrosyl-tRNA(Tyr) deacylase -
I6K43_RS22130 3874882..3875823 + 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
I6K43_RS22135 3875837..3876754 - 918 WP_004178029.1 alpha/beta hydrolase -
I6K43_RS22140 3876959..3877201 + 243 WP_004150355.1 ribbon-helix-helix domain-containing protein Antitoxin
I6K43_RS22145 3877201..3877584 + 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
I6K43_RS22150 3877758..3878687 - 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
I6K43_RS22155 3878684..3879319 - 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
I6K43_RS22160 3879316..3880218 - 903 WP_002882822.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T192125 WP_002882817.1 NZ_CP069907:3877201-3877584 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

>T192125 NZ_CP092075:4213765-4214694 [Salmonella enterica]
ATGGATCTGCGTGATAGTTATGCCCGACAGGTCAGGCTATTAATGACCGCCCTGCCGCATGTAGCAAAGGAGTCCTGCTT
CGCCCTGAAAGGCGGCACGGCAATAAATTTGTTTGTGCAGGATTTCCCTCGCCTCTCGGTAGATATCGATCTGGCGTACA
AGACCTATGCGGATCGCGATACCGATCTGGCTGCCATCAATGACGCCTTAATGCGCATTACGGAATCGCTGAACGACAGA
CCGGGGATCAGTGCTATCCGACAGGAGAATAAAGCGGATGAAAAGCGCATCATCGTCAACACCGCTGACGCGAAGATAAA
GATTGAGGTTAGTCCGGTCTGGCGTGGACTACTATTACCACCAACAGAAATGCCGGTATGTGAACAGGTGGAAATTGAAT
ATGGCTTCACCACCATGAATGTCGTCTCGCTGGCGGATCTTTACGGCGGTAAAATCTGCGCCGCGCTTGACCGCCAGCAT
CCGCGCGATCTGTTTGACGTGCTGAATATGCTGGAAAAGCCGGGCCTGACGCGTGAGATCTTTGACGGTTTTCTTTGCTA
TCTGGCAGGGCATCCCCGCCCCATTACCGAGCTGCTGGCACCAAACTGGGATACAGCGCGGATCACTACCCTGTACGCAC
AGGAATTTTCAGGCATGACACAGCAGGAAACATCGCTGGAATCCCTTTTATCAGTAACGACTTTGCTGCCACAAGCGCTG
AAATCGCATCTTACGGACAGAGATCGCCAGTTCTTGCTCCGCTATAAGCAAAATACCCCTGACTGGTCGCTGTATCGCTA
TCCTGAAATTCAACACCTACCAGCGATTCGCTGGAAGTCGCGTAACCTGGCGGTGCTGAAGGATAAGAATCCGGCCAAGT
ATGCGGCGGCGGTGAATAAGCTGGAGAGAGTTCTGGAGCAGTACCTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT192125 WP_004150355.1 NZ_CP069907:3876959-3877201 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT192125 NZ_CP092075:4212996-4213778 [Salmonella enterica]
TTGCCAAACTATCTAAACTGGCTGATGCAGAACACCCTCCCCGGTCAGGTGCTGCTCCAGTCATGGCTTACCCGTAATGG
CATAGATCGTAAGCTTTCTTACCTCTATGTCCAGAATGGCTGGCTCAGGCGGATCGCGCACGGCGTATACTGCCGGACGG
GCCGTGAACCAGACTGGGTGGACGCAGTTTACTGCCTGCAAACGCAGTGGGAAAAGCCAGTTCGCATGGCCGGGCTGACC
AGCCTTGCGCTACAGGGCTATGCCCACTATACCGAACCGGGCAGGCCGCAGGTCTGGCTGGCACTTCCGGCTTACGCCAA
ACTGCCGGGATGGTTTGTCGCCTTTGAGCAATCCGCGATGTTTGTCACACTGTATACCTCTGGTCTCACCGTCGATATAA
CACCATTCACGACAAAACTGAATATCGGCGACCGGCAGTTAATAGGCAGTGTCCCAGAACTGGCCGCGTATGAGATCGCC
TGCGGAGTACCCTCGTTGATCTCATTCGAACATGCCGACGCTCTGTTTCAGGGAATGAATCTTCTCAGCCCGCGAAAATT
ACAGGCTTTGCTCTGCGCCAGCCATTCAGTTAAAACCAACCGGGTGATGCTCTATCTTGCCCGACGCAACGAGCACCCTT
ACTTTCAGTACCTCGATCAAAGCGGTATAGAAACAGGCACTGGAAAACGGCAAATCGTTCCCGGCGGCTGGCTGGAGCCG
GATTATCAAATCACCGTTCCCCGCGCATTTAAACCGGAAGGAGTCGAAGATGGATCTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References