Detailed information of TA system TA192122

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ykfI-yfjZ/CbtA-CbeA
• Location: 3116827..3117530
• Replicon: chromosome
• Accession: NZ_CP069907
• Organism: Klebsiella pneumoniae strain FDAARGOS_1313

Toxin (Protein)

• Gene name: ykfI
• Uniprot ID: -
• Locus tag: I6K43_RS18410
• Protein ID: WP_009309675.1
• Coordinates: 3116827..3117168 (-)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: I6K43_RS18415
• Protein ID: WP_009309674.1
• Coordinates: 3117189..3117530 (-)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K43_RS18390	3112054..3113799	+	1746	WP_004149864.1	DNA primase	-
I6K43_RS18395	3114018..3115859	+	1842	WP_004174339.1	RNA polymerase sigma factor RpoD	-
I6K43_RS18400	3115959..3116465	-	507	WP_002917636.1	G/U mismatch-specific DNA glycosylase	-
I6K43_RS18410	3116827..3117168	-	342	WP_009309675.1	TA system toxin CbtA family protein	Toxin
I6K43_RS18415	3117189..3117530	-	342	WP_009309674.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
I6K43_RS18420	3117541..3118083	-	543	WP_009309673.1	DNA repair protein RadC	-
I6K43_RS18425	3118096..3118538	-	443	Protein_3042	antirestriction protein	-
I6K43_RS18430	3118569..3119390	-	822	WP_009309670.1	DUF945 domain-containing protein	-
I6K43_RS18435	3119588..3120460	-	873	WP_196983271.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (13-112)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12822.76 Da
• Isoelectric Point: 9.6542

>T192122 WP_009309675.1 NZ_CP069907:c3117168-3116827 [Klebsiella pneumoniae]
MKTLPATISRAAKPCLSPVAAWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAEITLADAVNFLVDKYGLVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLRRSRNNAVS

Nucleotide

• Length: 342 bp

>T192122 NZ_CP092075:3440351-3440569 [Salmonella enterica]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12735.41 Da
• Isoelectric Point: 6.3157

>AT192122 WP_009309674.1 NZ_CP069907:c3117530-3117189 [Klebsiella pneumoniae]
MKSTESENDLFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGAFSNAESLKLDEVFPRFISQMESMLTIGEMNPHH
AHCVTLYHNGFTCEADTLGSCGYVYIAVYPTQR

Nucleotide

• Length: 342 bp

>AT192122 NZ_CP092075:3439949-3440323 [Salmonella enterica]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA