192120

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2966744..2967401 Replicon chromosome
Accession NZ_CP069907
Organism Klebsiella pneumoniae strain FDAARGOS_1313

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag I6K43_RS17625 Protein ID WP_002916310.1
Coordinates 2966744..2967154 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag I6K43_RS17630 Protein ID WP_002916312.1
Coordinates 2967135..2967401 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K43_RS17605 2962744..2964477 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
I6K43_RS17610 2964483..2965196 - 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I6K43_RS17615 2965219..2966115 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
I6K43_RS17620 2966216..2966737 + 522 WP_004144730.1 flavodoxin FldB -
I6K43_RS17625 2966744..2967154 - 411 WP_002916310.1 protein YgfX Toxin
I6K43_RS17630 2967135..2967401 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
I6K43_RS17635 2967647..2968630 + 984 WP_009308615.1 tRNA-modifying protein YgfZ -
I6K43_RS17640 2968781..2969440 - 660 WP_002916317.1 hemolysin III family protein -
I6K43_RS17645 2969604..2969915 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
I6K43_RS17650 2969965..2970693 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
I6K43_RS17655 2970812..2972245 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T192120 WP_002916310.1 NZ_CP069907:c2967154-2966744 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T192120 NZ_CP092075:2074093-2074196 [Salmonella enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT192120 WP_002916312.1 NZ_CP069907:c2967401-2967135 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT192120 NZ_CP092075:c2074198-2074055 [Salmonella enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References