Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2966744..2967401 Replicon chromosome
Accession NZ_CP069907
Organism Klebsiella pneumoniae strain FDAARGOS_1313

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag I6K43_RS17625 Protein ID WP_002916310.1
Coordinates 2966744..2967154 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag I6K43_RS17630 Protein ID WP_002916312.1
Coordinates 2967135..2967401 (-) Length 89 a.a.

Genomic Context

I6K43_RS17620I6K43_RS17635I6K43_RS17650I6K43_RS17655I6K43_RS17605I6K43_RS17610I6K43_RS17615I6K43_RS17625I6K43_RS17630I6K43_RS17640I6K43_RS17645
Location: 2966216..2966737 (522 bp)
Type: Others
Protein ID: WP_004144730.1
Location: 2967647..2968630 (984 bp)
Type: Others
Protein ID: WP_009308615.1
Location: 2969965..2970693 (729 bp)
Type: Others
Protein ID: WP_002916321.1
Location: 2970812..2972245 (1434 bp)
Type: Others
Protein ID: WP_002916322.1
Location: 2962744..2964477 (1734 bp)
Type: Others
Protein ID: WP_004149758.1
Location: 2964483..2965196 (714 bp)
Type: Others
Protein ID: WP_004185548.1
Location: 2965219..2966115 (897 bp)
Type: Others
Protein ID: WP_004144729.1
Location: 2966744..2967154 (411 bp)
Type: Toxin
Protein ID: WP_002916310.1
Location: 2967135..2967401 (267 bp)
Type: Antitoxin
Protein ID: WP_002916312.1
Location: 2968781..2969440 (660 bp)
Type: Others
Protein ID: WP_002916317.1
Location: 2969604..2969915 (312 bp)
Type: Others
Protein ID: WP_004144734.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
I6K43_RS176052962744..2964477-1734WP_004149758.1single-stranded-DNA-specific exonuclease RecJ-
I6K43_RS176102964483..2965196-714WP_004185548.1bifunctional protein-disulfide isomerase/oxidoreductase DsbC-
I6K43_RS176152965219..2966115-897WP_004144729.1site-specific tyrosine recombinase XerD-
I6K43_RS176202966216..2966737+522WP_004144730.1flavodoxin FldB-
I6K43_RS176252966744..2967154-411WP_002916310.1protein YgfXToxin
I6K43_RS176302967135..2967401-267WP_002916312.1FAD assembly factor SdhEAntitoxin
I6K43_RS176352967647..2968630+984WP_009308615.1tRNA-modifying protein YgfZ-
I6K43_RS176402968781..2969440-660WP_002916317.1hemolysin III family protein-
I6K43_RS176452969604..2969915-312WP_004144734.1N(4)-acetylcytidine aminohydrolase-
I6K43_RS176502969965..2970693+729WP_002916321.1MurR/RpiR family transcriptional regulator-
I6K43_RS176552970812..2972245+1434WP_002916322.16-phospho-beta-glucosidase BglA-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T192120 WP_002916310.1 NZ_CP069907:c2967154-2966744 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T192120 NZ_CP092075:2074093-2074196 [Salmonella enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT192120 WP_002916312.1 NZ_CP069907:c2967401-2967135 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT192120 NZ_CP092075:c2074198-2074055 [Salmonella enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0H3GSW7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0H3GY41

References