Detailed information of TA system TA192111

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1160488..1162076
• Replicon: chromosome
• Accession: NZ_CP069907
• Organism: Klebsiella pneumoniae strain FDAARGOS_1313

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: I6K43_RS08650
• Protein ID: WP_048980818.1
• Coordinates: 1160754..1162076 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: I6K43_RS08645
• Protein ID: WP_002904790.1
• Coordinates: 1160488..1160754 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K43_RS08620	1155518..1156441	+	924	WP_048980813.1	LysR family hpxDE operon transcriptional regulator HpxR	-
I6K43_RS08625	1156422..1157576	-	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
I6K43_RS08630	1157922..1159301	+	1380	WP_004184021.1	purine permease	-
I6K43_RS08635	1159279..1159779	+	501	WP_048980815.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
I6K43_RS08640	1159776..1160102	+	327	WP_004184023.1	hydroxyisourate hydrolase	-
I6K43_RS08645	1160488..1160754	+	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
I6K43_RS08650	1160754..1162076	+	1323	WP_048980818.1	type II toxin-antitoxin system HipA family toxin	Toxin
I6K43_RS08655	1162093..1163385	-	1293	WP_015958402.1	glycoside hydrolase family 10 protein	-
I6K43_RS08660	1163527..1164531	-	1005	WP_009308876.1	type 1 fimbrial protein	-
I6K43_RS08665	1164519..1167008	-	2490	WP_048980820.1	fimbrial biogenesis outer membrane usher protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49125.44 Da
• Isoelectric Point: 7.5367

>T192111 WP_048980818.1 NZ_CP069907:1160754-1162076 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAVTENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T192111 NZ_CP092072:c2418428-2418162 [Staphylococcus argenteus]
ATGGCTAGGTTAAACATTACGTTCTCGCCTCAGGCATTTGAAGATTATGAGTATTTTCAGCAGAACGATAAAAAAATGGT
AAAGAAGATTAATGAGTTACTTAAAAGCATTGATAGAAATGGTGCATTGCAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATTTATTTGGCTATTATAGTAGACGTATCAATCACGAACATAGGTTGGTTTATACAGTTGACGATAATCACATAAAA
ATAGCATCCTGTAGATACCATTATTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT192111 WP_002904790.1 NZ_CP069907:1160488-1160754 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT192111 NZ_CP092072:c2418679-2418428 [Staphylococcus argenteus]
ATGATTGTAAAAAACTATTCTTACGCTAGACAGAATTTAAAGACGCTTATGACAAAGGTAAATGACGATAGTGATGTGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATTATGTCAGAAGCAGATTATAATTCTATAATTGAAACCCTTTACC
TTCAACAGAATCCAAATAATGCTGAACACTTAGCCCAATCAATTGCTGACTTAGAACGAGGCAAAATGGTAACGAAAGAA
ATAGATGTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GXD8