Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 340275..341041 Replicon plasmid unnamed4
Accession NZ_CP069904
Organism Klebsiella pneumoniae strain FDAARGOS_1313

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag I6K43_RS02630 Protein ID WP_032437998.1
Coordinates 340550..341041 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag I6K43_RS02625 Protein ID WP_162838098.1
Coordinates 340275..340562 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K43_RS02610 335423..336661 - 1239 WP_003030308.1 IS110 family transposase -
I6K43_RS02615 337082..338422 - 1341 WP_000589001.1 ISNCY family transposase -
I6K43_RS02620 338511..340043 + 1533 WP_015065592.1 IS3-like element ISKpn38 family transposase -
I6K43_RS02625 340275..340562 + 288 WP_162838098.1 DUF1778 domain-containing protein Antitoxin
I6K43_RS02630 340550..341041 + 492 WP_032437998.1 GNAT family N-acetyltransferase Toxin
I6K43_RS02635 341114..341287 + 174 WP_162838097.1 hypothetical protein -
I6K43_RS02640 341507..341854 - 348 WP_032437997.1 hypothetical protein -
I6K43_RS02645 342112..343404 - 1293 WP_048268720.1 ABC transporter ATP-binding protein/permease -
I6K43_RS02650 343392..343865 - 474 WP_129773333.1 hypothetical protein -
I6K43_RS02655 344596..345081 - 486 WP_204752704.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid formA pla 1..358127 358127
- flank IS/Tn - - 338511..340043 1532


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(29-149)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17688.45 Da        Isoelectric Point: 8.5281

>T192109 WP_032437998.1 NZ_CP069904:340550-341041 [Klebsiella pneumoniae]
VGKVTAPVPLSSSHVIAEFHCGEPVLDEWIKQRGLKNQSMGAARTFVVCRENASQVVGFYSLATGSVTHAVAPGSLRRNM
PDPVPVIILARLAVDAGYHGEGLGADLLHDAVLRCCRVAENIGVRAVMVHALSDRARQFYIHHGFIPSQTQERTLFLRLP
VVT

Download         Length: 492 bp

>T192109 NZ_CP092072:c2082209-2081847 [Staphylococcus argenteus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTTGT
CATTATTCAAAATGACACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCCA
AAATACCGACCCATGTAGAGATTGAAAAGAAAAAATATAAACTGGATAAAGATTCAGTTATATTATTAGAACAAATTCGG
ACACTTGATAAAAAACGTTTAAAAGAAAAACTGACGTACTTATCAGACAACAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTAAACACAATGGCTCATCAGAAAAATTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10868.54 Da        Isoelectric Point: 5.1530

>AT192109 WP_162838098.1 NZ_CP069904:340275-340562 [Klebsiella pneumoniae]
MLYTGGSMKSDVQLNIRAKEAQRALIDTAAEILHKSRTDFILEMACQAAENVILDRRMFNLNDEQYAEFIDILDAPVTAN
PAMEKLLARKPRWEK

Download         Length: 288 bp

>AT192109 NZ_CP092072:c2082376-2082206 [Staphylococcus argenteus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCAATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References