Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 332463..332989 Replicon plasmid unnamed4
Accession NZ_CP069904
Organism Klebsiella pneumoniae strain FDAARGOS_1313

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag I6K43_RS02590 Protein ID WP_000323025.1
Coordinates 332463..332750 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag I6K43_RS02595 Protein ID WP_000534858.1
Coordinates 332750..332989 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K43_RS02560 327509..327742 - 234 WP_004181905.1 hypothetical protein -
I6K43_RS02565 327821..328168 - 348 WP_004181904.1 hypothetical protein -
I6K43_RS02570 328324..329391 - 1068 WP_004181903.1 hypothetical protein -
I6K43_RS02575 330081..330458 + 378 WP_004181901.1 hypothetical protein -
I6K43_RS02580 330656..331630 - 975 WP_004181899.1 hypothetical protein -
I6K43_RS02585 332233..332391 - 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
I6K43_RS02590 332463..332750 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
I6K43_RS02595 332750..332989 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
I6K43_RS02600 333252..334175 - 924 WP_020277922.1 cation diffusion facilitator family transporter -
I6K43_RS02605 334375..334947 - 573 WP_001515348.1 cytochrome b/b6 domain-containing protein -
I6K43_RS02610 335423..336661 - 1239 WP_003030308.1 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid formA pla 1..358127 358127


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T192108 WP_000323025.1 NZ_CP069904:c332750-332463 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T192108 NZ_CP092072:c1985158-1984982 [Staphylococcus argenteus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT192108 WP_000534858.1 NZ_CP069904:c332989-332750 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT192108 NZ_CP092072:1984859-1984914 [Staphylococcus argenteus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References