Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 38027..38937 Replicon plasmid unnamed4
Accession NZ_CP069904
Organism Klebsiella pneumoniae strain FDAARGOS_1313

Toxin (Protein)


Gene name - Uniprot ID A0A5Q9LR54
Locus tag I6K43_RS01125 Protein ID WP_004181896.1
Coordinates 38027..38497 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A2J4RLY9
Locus tag I6K43_RS01130 Protein ID WP_004181895.1
Coordinates 38494..38937 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K43_RS01110 34459..35592 + 1134 WP_171888422.1 IS481-like element ISKpn28 family transposase -
I6K43_RS01120 37657..37917 + 261 WP_004026352.1 hypothetical protein -
I6K43_RS01125 38027..38497 - 471 WP_004181896.1 RES family NAD+ phosphorylase Toxin
I6K43_RS01130 38494..38937 - 444 WP_004181895.1 DUF2384 domain-containing protein Antitoxin
I6K43_RS01135 39038..40213 - 1176 Protein_40 translesion error-prone DNA polymerase V subunit UmuC -
I6K43_RS01140 40356..40814 + 459 Protein_41 recombinase family protein -
I6K43_RS01145 41065..41274 + 210 WP_072072310.1 microcin B17 -
I6K43_RS01150 41333..42187 + 855 WP_048268726.1 McbB family protein -
I6K43_RS01155 42189..42995 + 807 WP_048268727.1 SagB/ThcOx family dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid formA pla 1..358127 358127
- inside IScluster/Tn - - 34459..40814 6355


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17549.81 Da        Isoelectric Point: 4.6155

>T192106 WP_004181896.1 NZ_CP069904:c38497-38027 [Klebsiella pneumoniae]
VIFYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

>T192106 NZ_CP092072:c863547-863359 [Staphylococcus argenteus]
ATGACTTTACATTTTGCAATTTTATTTTGGCTAGCATTAATTTTTATCGTTGCTGGTACATTTATATTTGTCTTAATGAA
AAAAACTGCTAAAGAATCTAAAAAAGAATCTTATTTAAGCTTCGCTGTTATTTTCTATATTTTTGGATTCGCAATGCTAA
TTTATACATTAATATTTGGAATTCTTTAA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16536.87 Da        Isoelectric Point: 10.3013

>AT192106 WP_004181895.1 NZ_CP069904:c38937-38494 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp

>AT192106 NZ_CP092072:c863836-863576 [Staphylococcus argenteus]
ATGAAAAACATTCAATTAAATGCTATAAATTTAGTTATAACAATCATATTTGCTATCTTTAACATTATGATTACATATAA
CAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGCATTATCATTTGCGGTTCGATACTCATTGTATCGTTTACCATTG
CAATGATTACTAAATTCTGGTTAAGTGAAATATTATTTTTTATTAACATCGTGCTCGTTCTTTATTATATTTATCCAATT
TTTTATGATTTCATTAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Q9LR54

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4RLY9

References