Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3507947..3508745 | Replicon | chromosome |
| Accession | NZ_CP069893 | ||
| Organism | Escherichia coli strain FDAARGOS_1286 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | Q8VRA6 |
| Locus tag | I6K16_RS16790 | Protein ID | WP_000854730.1 |
| Coordinates | 3507947..3508324 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A0P0SQV8 |
| Locus tag | I6K16_RS16795 | Protein ID | WP_001285481.1 |
| Coordinates | 3508371..3508745 (-) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6K16_RS25325 (3503745) | 3503745..3503939 | - | 195 | WP_001313570.1 | DUF957 domain-containing protein | - |
| I6K16_RS16765 (3503981) | 3503981..3504272 | + | 292 | Protein_3289 | transposase | - |
| I6K16_RS16770 (3504269) | 3504269..3504619 | + | 351 | WP_000624707.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| I6K16_RS16775 (3504650) | 3504650..3506243 | + | 1594 | Protein_3291 | IS66 family transposase | - |
| I6K16_RS16780 (3506391) | 3506391..3507379 | + | 989 | Protein_3292 | IS630 family transposase | - |
| I6K16_RS16785 (3507458) | 3507458..3507950 | - | 493 | Protein_3293 | DUF5983 family protein | - |
| I6K16_RS16790 (3507947) | 3507947..3508324 | - | 378 | WP_000854730.1 | TA system toxin CbtA family protein | Toxin |
| I6K16_RS16795 (3508371) | 3508371..3508745 | - | 375 | WP_001285481.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| I6K16_RS16800 (3508795) | 3508795..3509439 | - | 645 | WP_000086759.1 | hypothetical protein | - |
| I6K16_RS16805 (3509458) | 3509458..3509679 | - | 222 | WP_000692315.1 | DUF987 domain-containing protein | - |
| I6K16_RS16810 (3509742) | 3509742..3510218 | - | 477 | WP_001313574.1 | RadC family protein | - |
| I6K16_RS16815 (3510234) | 3510234..3510707 | - | 474 | WP_001313575.1 | antirestriction protein | - |
| I6K16_RS16820 (3510801) | 3510801..3511046 | - | 246 | WP_001164966.1 | hypothetical protein | - |
| I6K16_RS16825 (3511046) | 3511046..3511867 | - | 822 | WP_001234359.1 | DUF932 domain-containing protein | - |
| I6K16_RS16830 (3511967) | 3511967..3512200 | - | 234 | WP_001213776.1 | DUF905 family protein | - |
| I6K16_RS16835 (3512318) | 3512318..3512770 | - | 453 | WP_000682723.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 3500494..3555906 | 55412 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14212.21 Da Isoelectric Point: 7.2923
>T192086 WP_000854730.1 NZ_CP069893:c3508324-3507947 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRSNYRMVNDIIRGEHSEAKR
MKTLPDTHVREASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRSNYRMVNDIIRGEHSEAKR
Download Length: 378 bp
>T192086 NZ_CP092062:c3573817-3573536 [Edwardsiella ictaluri]
ATGACCTATAAACTGAGCTTTGAAAAGCGAGCCCTGAAAGAGTGGAAAAAACTGGCACCGCCGATTCAAAGCCAGTTGAA
AAAGAAACTGATCGAACGCCTGGAAAACCCACATGTTCCAGCAGCACGCTTAAGTGGGCGCGCTAACCGTTATAAAATAA
AATTACGCTCTTCCGGTTACCGGTTAGTTTATGAAGTCAACGATAGCGAAATCATCCTGCTGGTGATCGCTATCGGTAAA
CGGGCCGATAACGAGGTGTACCAAGCGGCAGACAGTCGTTAG
ATGACCTATAAACTGAGCTTTGAAAAGCGAGCCCTGAAAGAGTGGAAAAAACTGGCACCGCCGATTCAAAGCCAGTTGAA
AAAGAAACTGATCGAACGCCTGGAAAACCCACATGTTCCAGCAGCACGCTTAAGTGGGCGCGCTAACCGTTATAAAATAA
AATTACGCTCTTCCGGTTACCGGTTAGTTTATGAAGTCAACGATAGCGAAATCATCCTGCTGGTGATCGCTATCGGTAAA
CGGGCCGATAACGAGGTGTACCAAGCGGCAGACAGTCGTTAG
Antitoxin
Download Length: 125 a.a. Molecular weight: 13817.53 Da Isoelectric Point: 4.7511
>AT192086 WP_001285481.1 NZ_CP069893:c3508745-3508371 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTIG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTIG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS
Download Length: 375 bp
>AT192086 NZ_CP092062:c3574058-3573807 [Edwardsiella ictaluri]
ATGGCATACCAAATTCTCACGACCACCGCCGCCAGCATTACCGACCTGAAACGCAATCCAATGGGTACCATTGCTGAAGG
TGACGGCAATGCCGTAGCAATCTTAAACCGGAATGAGCCGGCCTTTTACTGCGTTCCACCGGAACTCTACGCTTACTATC
TGGAGCTGGCTGAAGATGCGGCGCTTAATCGTATCGCCGATGAGCGTCTGGAGGACGCTGAGTTTGTCAGCGTAAATATC
GATGACCTATAA
ATGGCATACCAAATTCTCACGACCACCGCCGCCAGCATTACCGACCTGAAACGCAATCCAATGGGTACCATTGCTGAAGG
TGACGGCAATGCCGTAGCAATCTTAAACCGGAATGAGCCGGCCTTTTACTGCGTTCCACCGGAACTCTACGCTTACTATC
TGGAGCTGGCTGAAGATGCGGCGCTTAATCGTATCGCCGATGAGCGTCTGGAGGACGCTGAGTTTGTCAGCGTAAATATC
GATGACCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H2V671 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0P0SQV8 |