Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2428249..2429084 Replicon chromosome
Accession NZ_CP069893
Organism Escherichia coli strain FDAARGOS_1286

Toxin (Protein)


Gene name yeeV Uniprot ID F4TIK8
Locus tag I6K16_RS11705 Protein ID WP_000854694.1
Coordinates 2428707..2429084 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8S7S1S5
Locus tag I6K16_RS11700 Protein ID WP_065793167.1
Coordinates 2428249..2428617 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K16_RS11665 (2424101) 2424101..2424781 + 681 WP_001282919.1 WYL domain-containing protein -
I6K16_RS11670 (2424929) 2424929..2425606 + 678 WP_001097305.1 hypothetical protein -
I6K16_RS11675 (2425612) 2425612..2425845 + 234 WP_001278287.1 DUF905 family protein -
I6K16_RS11680 (2425935) 2425935..2426753 + 819 WP_001175149.1 DUF932 domain-containing protein -
I6K16_RS11685 (2426835) 2426835..2427314 + 480 WP_000860065.1 antirestriction protein -
I6K16_RS11690 (2427326) 2427326..2427802 + 477 WP_001186710.1 RadC family protein -
I6K16_RS11695 (2427865) 2427865..2428086 + 222 WP_000692303.1 DUF987 domain-containing protein -
I6K16_RS11700 (2428249) 2428249..2428617 + 369 WP_065793167.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
I6K16_RS11705 (2428707) 2428707..2429084 + 378 WP_000854694.1 TA system toxin CbtA family protein Toxin
I6K16_RS11710 (2429081) 2429081..2429230 + 150 Protein_2310 DUF5983 family protein -
I6K16_RS11715 (2429306) 2429306..2429503 + 198 WP_086795284.1 DUF957 domain-containing protein -
I6K16_RS11720 (2429588) 2429588..2430430 + 843 WP_001696593.1 DUF4942 domain-containing protein -
I6K16_RS11725 (2431026) 2431026..2431523 + 498 WP_000509808.1 hypothetical protein -
I6K16_RS11730 (2431690) 2431690..2432613 + 924 WP_000535959.1 carboxylate/amino acid/amine transporter -
I6K16_RS11735 (2432617) 2432617..2433435 - 819 WP_000779405.1 lipoprotein NlpA -
I6K16_RS11740 (2433657) 2433657..2433950 + 294 WP_001297978.1 protein YicS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14008.02 Da        Isoelectric Point: 7.7293

>T192083 WP_000854694.1 NZ_CP069893:2428707-2429084 [Escherichia coli]
MKTLPDTHVREASCCPSPVTIWQTLLTRLLDQHYGLALNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T192083 NZ_CP092062:2159051-2159707 [Edwardsiella ictaluri]
ATGGCTTATGATTACAGCGCCAACCTCAACCCGGAAAAAGCCCTGATCTGGCGCATTGTCCATCGGGATAATATCCCGTG
GATACTGGACCACGGTCTGCACTGCGGCAACAGCCCGGTGCAGGCGGCAAACTGGATCAATATCGGCAACCCGGAACTTA
TCGGCAAACGCGCCGGGCATCCGGTGCCTGTCGGTATGGGCGGGACGCTGCATGACTACGTGCCGTTTTACTTTACCCCC
TTTTCGCCGATGCTGATGAATATCCACAGCGGGCGTGGCGGCATTACGCAGCGCCCCAATGAGGAAATCGTCATTCTGGT
CAGCAACCTGCGAAACGTGGCGGCGCAGAACATCCCCTTCGTGTTTACCGACAGCCACGCCTACTATAACTGGGTCAACT
ACTACACCCGTCTGGACGATCTGAACCAGATCGACTGGTCTATCTTACAGGCGCGGGATTTCCGTCGCGATCCGGACGAT
CCGGCGAAGTTTGAACGCTATCAGGCCGAGGCGTTAATCTGGAAGCACTGCCCCATCACACTGCTGGTCGGGATGATTTG
TTACAACGATGGCGTCAGGTTACAATTAGAGCAGTGGCTGTCGCAACGTAATCTGACAATGCCCGTTCACGCACGGGCCG
GGTGGTACTTCTCATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13555.50 Da        Isoelectric Point: 6.6249

>AT192083 WP_065793167.1 NZ_CP069893:2428249-2428617 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT192083 NZ_CP092062:2159704-2160771 [Edwardsiella ictaluri]
ATGATCACATATACACAAGGCAATTTACTGGACGCGCCCGTGGAAGCACTGGTGAATACGGTGAATACCGTCGGTGTCAT
GGGTAAAGGCATCGCGCTGATGTTTAAAGAGCGCTTCCCCGACAATATGAAAGCCTATGCCGACGCCTGCAAACAAAAGC
AGGTGATGACCGGCAAGATGTTTATTACCGAAACCGGCGAGCTGATGGGGCCACGCTGGATCGTCAACTTCCCTACCAAG
CAGCACTGGCGCGCCGACTCCCGCATGGCGTGGATCGAAGACGGTTTGCAGGACTTGCGCCGCTTTTTGATCGAAGAAAA
CGTGCAGTCCATCGCCATTCCCCCGCTGGGCGCGGGCAACGGCGGCCTGAACTGGCCGGATGTCCGGGCGCGGATTGAAT
CTGCGCTGGGCGACCTTCAGGACACGGAAATCCTGATTTATGAGCCTACCGAAAAATACCAGAACGTCGCCAAGAGCAGC
GGCGTAAAAAAGCTCACCCCCGCCAGAGCGATGATCGCTGAACTGGTGCGCCGCTACTGGGTGCTGGGTATGGAGTGCAG
CCTGCTGGAAATCCAGAAGCTGGCATGGCTGCTACAACGCGCCATTGAACAGCACCAGCAGGAGGACGTGCTAAAACTGC
GGTTTGAGGCGCACTATTACGGCCCCTATGCTCCTAACCTGAACCATCTGCTTAACGCGCTGGACGGTACCTATCTGAAA
GCCGAAAAGCGTATCCCGGACAGCCAGCCACTGGATGTGATCTGGTTTAACGATCGGGAAAAAGAACACATCAACCTCTG
GCTGAACAGCGAAGCCAAAGCGTGGTTGCCAGCGCTTGAGCAGGTCAGCCAGTTGATTGACGGTTTTGAATCGCCGTTTG
GTCTGGAGCTGTTGGCGACCGTTGACTGGTTGTTGACCCGGGGACAATGCCAGCCGACGCTGGACTCGGTGAAAGAGGGG
TTGCATCAGTGGCCTGCGGGAGAACCTTGGGCCAGCCGTAAGATAAAGCTGTTTGACGATAAGAATCTGCAATTCGCCAT
TAACCGCGTGATGGAGTTTCATTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M2F934

Antitoxin

Source ID Structure

References