Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1072244..1072869 Replicon chromosome
Accession NZ_CP069893
Organism Escherichia coli strain FDAARGOS_1286

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag I6K16_RS05280 Protein ID WP_000911329.1
Coordinates 1072244..1072642 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag I6K16_RS05285 Protein ID WP_000450524.1
Coordinates 1072642..1072869 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K16_RS05260 (1068151) 1068151..1068351 + 201 WP_000383836.1 YpfN family protein -
I6K16_RS05265 (1068432) 1068432..1069130 - 699 WP_000679819.1 esterase -
I6K16_RS05270 (1069204) 1069204..1071219 - 2016 WP_000829310.1 tRNA cytosine(34) acetyltransferase TmcA -
I6K16_RS05275 (1071234) 1071234..1072097 - 864 WP_001267498.1 neutral zinc metallopeptidase -
I6K16_RS05280 (1072244) 1072244..1072642 - 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
I6K16_RS05285 (1072642) 1072642..1072869 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
I6K16_RS05290 (1073026) 1073026..1073739 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
I6K16_RS05295 (1073952) 1073952..1074986 - 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
I6K16_RS05300 (1075003) 1075003..1075881 - 879 WP_204669799.1 4-hydroxy-tetrahydrodipicolinate synthase -
I6K16_RS05305 (1076027) 1076027..1076599 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
I6K16_RS05310 (1076599) 1076599..1077069 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T192072 WP_000911329.1 NZ_CP069893:c1072642-1072244 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T192072 NZ_CP092052:c2461249-2460983 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT192072 WP_000450524.1 NZ_CP069893:c1072869-1072642 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT192072 NZ_CP092052:c2461500-2461249 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGTTATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References