Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4872021..4872852 Replicon chromosome
Accession NZ_CP069890
Organism Escherichia coli strain FDAARGOS_1295

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag I6K25_RS23445 Protein ID WP_000854814.1
Coordinates 4872478..4872852 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1PWQ3
Locus tag I6K25_RS23440 Protein ID WP_001285586.1
Coordinates 4872021..4872389 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K25_RS23405 (4867079) 4867079..4868149 + 1071 WP_000102631.1 patatin-like phospholipase family protein -
I6K25_RS23410 (4868285) 4868285..4868962 + 678 WP_001362823.1 hypothetical protein -
I6K25_RS23415 (4868978) 4868978..4869388 + 411 WP_000846704.1 hypothetical protein -
I6K25_RS23420 (4869609) 4869609..4870430 + 822 WP_001234570.1 DUF932 domain-containing protein -
I6K25_RS23425 (4870693) 4870693..4871166 + 474 WP_000855071.1 antirestriction protein -
I6K25_RS23430 (4871181) 4871181..4871657 + 477 WP_001298074.1 RadC family protein -
I6K25_RS23435 (4871726) 4871726..4871947 + 222 WP_000692323.1 DUF987 domain-containing protein -
I6K25_RS23440 (4872021) 4872021..4872389 + 369 WP_001285586.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
I6K25_RS23445 (4872478) 4872478..4872852 + 375 WP_000854814.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
I6K25_RS23450 (4872849) 4872849..4873043 + 195 WP_000988601.1 DUF5983 family protein -
I6K25_RS23455 (4873089) 4873089..4873169 + 81 Protein_4622 hypothetical protein -
I6K25_RS25165 (4873458) 4873458..4873538 - 81 WP_023441679.1 hypothetical protein -
I6K25_RS25170 (4873517) 4873517..4873840 + 324 WP_223216378.1 EutP/PduV family microcompartment system protein -
I6K25_RS23470 (4873941) 4873941..4874270 - 330 WP_000450409.1 DUF496 family protein -
I6K25_RS23475 (4874442) 4874442..4875500 - 1059 WP_001200890.1 FUSC family protein -
I6K25_RS23480 (4875698) 4875698..4876171 - 474 WP_001105376.1 DNA gyrase inhibitor SbmC -
I6K25_RS23485 (4876290) 4876290..4877455 - 1166 Protein_4628 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T192060 WP_000854814.1 NZ_CP069890:4872478-4872852 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T192060 NZ_CP092042:c4009423-4009010 [Enterobacter cloacae]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCGTTATTGCTCCACGGCCTGGTCGCGGC
ATTTGTTTTACTGATGCCGTGGCCGCTTAGCTATACGCCGCTGTGGCTGTTGTTGCTGTCGTTCGTCGTTTTTGACAGCG
TGCGCAGCCAGCGCCGGATCAATGCCCGCCAGGGTGAGATTAAATTACTGATGGACTCCCGCCTGCGCTGGCAGGGTAAA
GAGTGGGATATCCTCGGTATGCCCTGGATGCTCAGTTCCGGCATGATGCTACGGTTACGCCAGGTGGGCGGCGGTAAGTG
CCAGCATCTGTGGCTGGCCGCCGACAGTATGGATATTGCGGAGTGGCGGGAACTGCGCCGGATGCTACTGCAGCAGCAAC
CGACGCAGGAATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13563.41 Da        Isoelectric Point: 5.0468

>AT192060 WP_001285586.1 NZ_CP069890:4872021-4872389 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT192060 NZ_CP092042:c4009670-4009404 [Enterobacter cloacae]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCATGCCGACGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGAGGATAAGCGTCTGTTTGTTCGCCTGCTTGAATCTGACGATCCCGATT
TATTCAACTGGCTGATGAACCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB S1PWQ3

References