Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3784596..3785394 | Replicon | chromosome |
| Accession | NZ_CP069890 | ||
| Organism | Escherichia coli strain FDAARGOS_1295 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | Q1RDD2 |
| Locus tag | I6K25_RS17985 | Protein ID | WP_001094434.1 |
| Coordinates | 3785020..3785394 (+) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | I6K25_RS17980 | Protein ID | WP_001552747.1 |
| Coordinates | 3784596..3784973 (+) | Length | 126 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6K25_RS17950 (3781474) | 3781474..3782295 | + | 822 | WP_001234585.1 | DUF932 domain-containing protein | - |
| I6K25_RS17955 (3782295) | 3782295..3782540 | + | 246 | WP_001164966.1 | hypothetical protein | - |
| I6K25_RS17960 (3782634) | 3782634..3783107 | + | 474 | WP_001542276.1 | antirestriction protein | - |
| I6K25_RS17965 (3783123) | 3783123..3783599 | + | 477 | WP_001186727.1 | RadC family protein | - |
| I6K25_RS17970 (3783662) | 3783662..3783883 | + | 222 | WP_000692315.1 | DUF987 domain-containing protein | - |
| I6K25_RS17975 (3783902) | 3783902..3784546 | + | 645 | WP_000086759.1 | hypothetical protein | - |
| I6K25_RS17980 (3784596) | 3784596..3784973 | + | 378 | WP_001552747.1 | type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA | Antitoxin |
| I6K25_RS17985 (3785020) | 3785020..3785394 | + | 375 | WP_001094434.1 | TA system toxin CbtA family protein | Toxin |
| I6K25_RS17990 (3785391) | 3785391..3785882 | + | 492 | WP_000976859.1 | DUF5983 family protein | - |
| I6K25_RS17995 (3785894) | 3785894..3786091 | + | 198 | WP_000839257.1 | DUF957 domain-containing protein | - |
| I6K25_RS18000 (3786184) | 3786184..3787026 | + | 843 | WP_001280460.1 | DUF4942 domain-containing protein | - |
| I6K25_RS18010 (3787497) | 3787497..3788435 | + | 939 | WP_000351298.1 | glyoxylate/hydroxypyruvate reductase GhrA | - |
| I6K25_RS18015 (3788490) | 3788490..3789227 | + | 738 | WP_000283664.1 | zinc-binding phosphatase | - |
| I6K25_RS18020 (3789251) | 3789251..3789805 | + | 555 | WP_001001909.1 | molecular chaperone YcdY | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13921.82 Da Isoelectric Point: 6.8517
>T192045 WP_001094434.1 NZ_CP069890:3785020-3785394 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK
Download Length: 375 bp
>T192045 NZ_CP092040:c4251817-4251332 [Salmonella enterica subsp. enterica serovar Infantis]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG
Antitoxin
Download Length: 126 a.a. Molecular weight: 13757.63 Da Isoelectric Point: 6.3127
>AT192045 WP_001552747.1 NZ_CP069890:3784596-3784973 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRTGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRTGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV
Download Length: 378 bp
>AT192045 NZ_CP092040:c4252092-4251805 [Salmonella enterica subsp. enterica serovar Infantis]
ATGCTATACAAAGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCAGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA
ATGCTATACAAAGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCAGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|