Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 2140012..2140937 Replicon chromosome
Accession NZ_CP069890
Organism Escherichia coli strain FDAARGOS_1295

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag I6K25_RS10220 Protein ID WP_014640052.1
Coordinates 2140551..2140937 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag I6K25_RS10215 Protein ID WP_001339382.1
Coordinates 2140012..2140521 (+) Length 170 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K25_RS10190 (2136111) 2136111..2136479 + 369 WP_000002899.1 diacylglycerol kinase -
I6K25_RS10195 (2136589) 2136589..2137197 + 609 WP_000646078.1 transcriptional repressor LexA -
I6K25_RS10200 (2137270) 2137270..2138595 + 1326 WP_001296637.1 MATE family efflux transporter DinF -
I6K25_RS10205 (2138711) 2138711..2138920 + 210 WP_001296638.1 CsbD family protein -
I6K25_RS10210 (2138962) 2138962..2139477 - 516 WP_000416264.1 zinc uptake transcriptional repressor Zur -
I6K25_RS10215 (2140012) 2140012..2140521 + 510 WP_001339382.1 Panacea domain-containing protein Antitoxin
I6K25_RS10220 (2140551) 2140551..2140937 + 387 WP_014640052.1 hypothetical protein Toxin
I6K25_RS10225 (2140977) 2140977..2141150 + 174 WP_021549909.1 hypothetical protein -
I6K25_RS10230 (2141198) 2141198..2141479 - 282 WP_001093919.1 pyocin activator PrtN family protein -
I6K25_RS10235 (2141516) 2141516..2142088 - 573 WP_021549910.1 3'-5' exonuclease -
I6K25_RS10240 (2142088) 2142088..2142684 - 597 WP_021549911.1 DUF551 domain-containing protein -
I6K25_RS10245 (2142688) 2142688..2142975 - 288 WP_021549912.1 hypothetical protein -
I6K25_RS10250 (2142977) 2142977..2143657 - 681 WP_021549913.1 ead/Ea22-like family protein -
I6K25_RS10255 (2143659) 2143659..2143958 - 300 WP_021549914.1 hypothetical protein -
I6K25_RS10260 (2143955) 2143955..2144374 - 420 WP_021549915.1 hypothetical protein -
I6K25_RS10265 (2144365) 2144365..2144901 - 537 WP_000008178.1 5'-deoxynucleotidase -
I6K25_RS10270 (2145030) 2145030..2145854 - 825 WP_204628101.1 DUF2303 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2136111..2200438 64327


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(6-116)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14465.40 Da        Isoelectric Point: 5.4833

>T192037 WP_014640052.1 NZ_CP069890:2140551-2140937 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Download         Length: 387 bp

>T192037 NZ_CP092040:442407-442691 [Salmonella enterica subsp. enterica serovar Infantis]
ATGAATTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 170 a.a.        Molecular weight: 19576.29 Da        Isoelectric Point: 5.3338

>AT192037 WP_001339382.1 NZ_CP069890:2140012-2140521 [Escherichia coli]
MAYLKLMKLLYLSNRQSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYNLIETNGHNVSLRSDPREMDAD
EVFDELSRADIRILDEIYSRYGHMNRFDLANMTHLESVCPEWHDPGNSRKPIDLKEMLISEGKSEDEANRIIGKMEESQK
LKEFSLQLS

Download         Length: 510 bp

>AT192037 NZ_CP092040:442175-442417 [Salmonella enterica subsp. enterica serovar Infantis]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCCTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGAATTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References