Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 3979..4622 Replicon plasmid unnamed1
Accession NZ_CP069883
Organism Escherichia coli strain FDAARGOS_1289

Toxin (Protein)


Gene name vagD Uniprot ID C7S9Y5
Locus tag I6K19_RS24745 Protein ID WP_001034046.1
Coordinates 3979..4395 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID V0SR71
Locus tag I6K19_RS24750 Protein ID WP_001261278.1
Coordinates 4392..4622 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K19_RS24740 (140) 140..3934 + 3795 WP_001144732.1 hypothetical protein -
I6K19_RS24745 (3979) 3979..4395 - 417 WP_001034046.1 type II toxin-antitoxin system VapC family toxin Toxin
I6K19_RS24750 (4392) 4392..4622 - 231 WP_001261278.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
I6K19_RS24755 (4887) 4887..5387 + 501 WP_000528931.1 HEPN family nuclease -
I6K19_RS24760 (5400) 5400..6173 + 774 WP_000905949.1 hypothetical protein -
I6K19_RS24765 (6406) 6406..7977 - 1572 WP_000381395.1 IS66-like element ISCro1 family transposase -
I6K19_RS24770 (7997) 7997..8344 - 348 WP_000624622.1 IS66 family insertion sequence element accessory protein TnpB -
I6K19_RS24775 (8344) 8344..9021 - 678 WP_001299364.1 IS66-like element accessory protein TnpA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aph(6)-Id / aph(3'')-Ib / sul2 / blaTEM-1B / dfrA8 / tet(B) - 1..131034 131034


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14978.31 Da        Isoelectric Point: 6.7113

>T192028 WP_001034046.1 NZ_CP069883:c4395-3979 [Escherichia coli]
VNKIYMLDTNICSFIMREQPEAVLKNLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCARLDAILPWDRA
AVDATTEVKVALRLAGTPIGPNDTAIAGHAIATGAILVTNNVREFERVPGLVLEDWAG

Download         Length: 417 bp

>T192028 NZ_CP092039:c3731057-3730482 [Pectobacterium brasiliense]
ATGAATCACTCCCCCTATCCTGTGGTACTTGATGCGTGTGTCATTTATCCATCTTTGCTACGGGATTTGCTCATGCATCT
TGGTTTAACAGGGCTATATCAGCCAAAGTGGACGGTACTAATTCAGGAAGAGTGGCAGCGAAATTTGTTGCTAAATAATG
CAGACGTAACGATGGATAAGCTCAGGAACATTGAGCATTTGATGAATAAGGCATTACCTGATGCCAATGTGACTGGGTTC
GAACAACTTATCCCTGCTCTGGTTTTACCTGATGCGGATGATCGACATGTATTGGCCGCTGCGATACGCGCTAATGCAGA
AGTTATCGTCACGGCAAATCTGAAAGATTTTCCAGCCACGTCACTTTCCGAATTTGGAGTGGAAGCCATGCACCCAGACG
AATTCATTGCCGATTTATTTGATCTCAATTCTGCACTGGTGCTTAAAGCCGTTCGAACTTCGCGAACAGCCTTCAGAAAG
CCTCCATTTGATGTGGACGAGTATCTGGATTGTCTCCTGCGTCAGGGGTTACCTATGACGGTAAAAGAACTGGATGCGTA
TCGAGCACTGATTTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8853.07 Da        Isoelectric Point: 4.6437

>AT192028 WP_001261278.1 NZ_CP069883:c4622-4392 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDRIILRPLRPSWSSFLELEKADPGFMTEREDVVCDEGRFNL

Download         Length: 231 bp

>AT192028 NZ_CP092039:c3731518-3731057 [Pectobacterium brasiliense]
ATGAAAAATACTCCTCTAAATAGTTTGAGCCTTCCGGCTCCAAAAGAAATGGAGGCCGCTATCCGTGGACAAAGGCAGCT
TGCAACTTACCTGTCTACGAAGCTGGAAACACAGGAAATTTCGATTCAGGATGCGCACGACATTGCCCATCGGATCGAGT
TGCCTACCTCAGCACTCACGCTTTTGATGAGTATCCTTGGCGAACTGGCGGCGGGTAATGCTGTCCAGATTGTCCCTGTG
CAGGCTGAATTAACGACACAAGAAGCGGCAAATATTCTGAATGTTTCACGGCCACATATGGTGAAGCTTTTGGAAGAAGG
CCATCTTCCTTTCCATAAAACAGGTCGTCATCGCCGCGTGCTTTTTGCTGATTTGATGCAATACAAAGAACAGCGTGAAA
ATGAAAGTATGCAAGCCATGCAGGAGCTGACAGACCGAAGTCAGGAATTCGGGTTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9NXF9

Antitoxin

Source ID Structure
AlphaFold DB V0SR71

References