Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 5171726..5172380 Replicon chromosome
Accession NZ_CP069882
Organism Escherichia coli strain FDAARGOS_1289

Toxin (Protein)


Gene name cptA Uniprot ID B7N7E0
Locus tag I6K19_RS24710 Protein ID WP_000244769.1
Coordinates 5171726..5172133 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag I6K19_RS24715 Protein ID WP_000354046.1
Coordinates 5172114..5172380 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K19_RS24690 (5167683) 5167683..5169416 - 1734 WP_000813190.1 single-stranded-DNA-specific exonuclease RecJ -
I6K19_RS24695 (5169422) 5169422..5170132 - 711 WP_000715210.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I6K19_RS24700 (5170157) 5170157..5171053 - 897 WP_000806652.1 site-specific tyrosine recombinase XerD -
I6K19_RS24705 (5171165) 5171165..5171686 + 522 WP_001055874.1 flavodoxin FldB -
I6K19_RS24710 (5171726) 5171726..5172133 - 408 WP_000244769.1 protein YgfX Toxin
I6K19_RS24715 (5172114) 5172114..5172380 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
I6K19_RS24720 (5172623) 5172623..5173603 + 981 WP_000886049.1 tRNA-modifying protein YgfZ -
I6K19_RS24725 (5173680) 5173680..5174339 - 660 WP_000250274.1 hemolysin III family protein -
I6K19_RS24730 (5174503) 5174503..5174814 - 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
I6K19_RS24735 (5174859) 5174859..5176292 + 1434 WP_001513393.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16062.03 Da        Isoelectric Point: 11.5554

>T192027 WP_000244769.1 NZ_CP069882:c5172133-5171726 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGK
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T192027 NZ_CP092039:3523513-3523716 [Pectobacterium brasiliense]
ATGAAAAAAATCGACTATTTGATGCGTTTGCGTAAATGCACAACCATTGACACTCTCGAACGCGTTATTGAAAAAAACAA
GTATGAACTCTCTAATGATGAACTGGAGATGTTCTTTTCCGCAGCCGATCATCGCCTTGCAGAACTGACGATGAACAAAC
TCTACGACAAAGTCCCTACTGCAGTATGGCGATACGTTCGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT192027 WP_000354046.1 NZ_CP069882:c5172380-5172114 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT192027 NZ_CP092039:3523091-3523459 [Pectobacterium brasiliense]
ATGGATGAGTACACACCAAAACATTATGATATTGCCCAACTCAGATTCTTATGTGAGAATCTGTGTGACGAAAGCATAGC
GACGTTAGGCGATAGCAGTCACGGCTGGGTCAATGATCCAACATCTGCGATCAATCTCCAATTAAATGAACTTATTGAGC
ATATCGCTACGTTTATTCTCACATTTAAAATAAAATACCCTAACGAAAGTGAGCTTTCAGAGCAGGTTGAAAAGTATTTG
GATGATACTTACGTCTTGTTTAGCAACTATGGTATTAATGATGCTGAACTACGGCGTTGGCAGAAGTCCAAAGCAAAATT
ATTCGGAATGTTCTCAGGGGAGAACATCTGTACGCCTGCTAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829J3T1

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References