Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 3474944..3475582 Replicon chromosome
Accession NZ_CP069882
Organism Escherichia coli strain FDAARGOS_1289

Toxin (Protein)


Gene name hicA Uniprot ID B7N4J4
Locus tag I6K19_RS16580 Protein ID WP_000813797.1
Coordinates 3474944..3475120 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag I6K19_RS16585 Protein ID WP_076611057.1
Coordinates 3475166..3475582 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K19_RS16560 (3470566) 3470566..3471738 - 1173 WP_251301794.1 BenE family transporter YdcO -
I6K19_RS16565 (3471830) 3471830..3472366 + 537 WP_000429161.1 DNA-binding transcriptional regulator SutR -
I6K19_RS16570 (3472439) 3472439..3474400 + 1962 WP_001309488.1 23S rRNA 5-hydroxycytidine C2501 synthase -
I6K19_RS16575 (3474492) 3474492..3474722 - 231 WP_000494244.1 YncJ family protein -
I6K19_RS16580 (3474944) 3474944..3475120 + 177 WP_000813797.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
I6K19_RS16585 (3475166) 3475166..3475582 + 417 WP_076611057.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
I6K19_RS16590 (3475661) 3475661..3477067 + 1407 WP_000760613.1 PLP-dependent aminotransferase family protein -
I6K19_RS16595 (3477312) 3477312..3478457 + 1146 WP_000047447.1 ABC transporter substrate-binding protein -
I6K19_RS16600 (3478475) 3478475..3479488 + 1014 WP_000220413.1 ABC transporter ATP-binding protein -
I6K19_RS16605 (3479489) 3479489..3480430 + 942 WP_001251335.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6724.76 Da        Isoelectric Point: 11.5666

>T192015 WP_000813797.1 NZ_CP069882:3474944-3475120 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFQGRRSVMPRHPSDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T192015 NZ_CP092037:c3364754-3364647 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15251.65 Da        Isoelectric Point: 4.5908

>AT192015 WP_076611057.1 NZ_CP069882:3475166-3475582 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLTNNDHFIEVPLSIASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT192015 NZ_CP092037:3364802-3364868 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829J715

Antitoxin

Source ID Structure

References