Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2337892..2338510 Replicon chromosome
Accession NZ_CP069882
Organism Escherichia coli strain FDAARGOS_1289

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag I6K19_RS11100 Protein ID WP_001291435.1
Coordinates 2337892..2338110 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag I6K19_RS11105 Protein ID WP_000344800.1
Coordinates 2338136..2338510 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K19_RS11065 (2333181) 2333181..2333753 + 573 WP_000779826.1 YbaY family lipoprotein -
I6K19_RS11070 (2333784) 2333784..2334095 - 312 WP_000409911.1 MGMT family protein -
I6K19_RS11080 (2334474) 2334474..2334827 + 354 WP_000878140.1 DUF1428 domain-containing protein -
I6K19_RS11085 (2334869) 2334869..2336419 - 1551 WP_001389864.1 cyclic-guanylate-specific phosphodiesterase PdeB -
I6K19_RS11090 (2336583) 2336583..2337053 - 471 WP_000136192.1 YlaC family protein -
I6K19_RS11095 (2337169) 2337169..2337720 - 552 WP_000102559.1 maltose O-acetyltransferase -
I6K19_RS11100 (2337892) 2337892..2338110 - 219 WP_001291435.1 HHA domain-containing protein Toxin
I6K19_RS11105 (2338136) 2338136..2338510 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
I6K19_RS11110 (2339056) 2339056..2342205 - 3150 WP_001132480.1 efflux RND transporter permease AcrB -
I6K19_RS11115 (2342228) 2342228..2343421 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T192006 WP_001291435.1 NZ_CP069882:c2338110-2337892 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T192006 NZ_CP092037:c1743110-1743007 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT192006 WP_000344800.1 NZ_CP069882:c2338510-2338136 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT192006 NZ_CP092037:1742969-1743240 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References