Detailed information of TA system TA192004

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 1474367..1475202
• Replicon: chromosome
• Accession: NZ_CP069882
• Organism: Escherichia coli strain FDAARGOS_1289

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A5F0P695
• Locus tag: I6K19_RS06975
• Protein ID: WP_022645116.1
• Coordinates: 1474367..1474744 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: I6K19_RS06980
• Protein ID: WP_078046143.1
• Coordinates: 1474834..1475202 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K19_RS06955 (1470734)	1470734..1472272	-	1539	WP_001187196.1	lysine decarboxylation/transport transcriptional activator CadC	-
I6K19_RS06960 (1473021)	1473021..1473863	-	843	WP_022645115.1	DUF4942 domain-containing protein	-
I6K19_RS06965 (1473948)	1473948..1474142	-	195	WP_024181941.1	DUF957 domain-containing protein	-
I6K19_RS06970 (1474221)	1474221..1474370	-	150	Protein_1366	DUF5983 family protein	-
I6K19_RS06975 (1474367)	1474367..1474744	-	378	WP_022645116.1	TA system toxin CbtA family protein	Toxin
I6K19_RS06980 (1474834)	1474834..1475202	-	369	WP_078046143.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
I6K19_RS06985 (1475365)	1475365..1475586	-	222	WP_000692345.1	DUF987 domain-containing protein	-
I6K19_RS06990 (1475649)	1475649..1476125	-	477	WP_022645117.1	RadC family protein	-
I6K19_RS06995 (1476141)	1476141..1476620	-	480	WP_001564060.1	antirestriction protein	-
I6K19_RS07000 (1476886)	1476886..1477704	-	819	WP_001175165.1	DUF932 domain-containing protein	-
I6K19_RS07005 (1477794)	1477794..1478027	-	234	WP_001278293.1	DUF905 family protein	-
I6K19_RS07010 (1478033)	1478033..1478710	-	678	WP_001097302.1	hypothetical protein	-
I6K19_RS07015 (1478858)	1478858..1479538	-	681	WP_001282921.1	WYL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1462922..1509753	46831

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14021.99 Da
• Isoelectric Point: 7.8045

>T192004 WP_022645116.1 NZ_CP069882:c1474744-1474367 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGIALCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRSNYRTVNNITRGKHPEAKQ

Nucleotide

• Length: 378 bp

>T192004 NZ_CP092037:c1423045-1421723 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13602.39 Da
• Isoelectric Point: 6.7390

>AT192004 WP_078046143.1 NZ_CP069882:c1475202-1474834 [Escherichia coli]
VSDTLSGATHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYHLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT192004 NZ_CP092037:c1423311-1423045 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Structures

Toxin

• AlphaFold DB: A0A5F0P695