Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 850969..851581 Replicon chromosome
Accession NZ_CP069882
Organism Escherichia coli strain FDAARGOS_1289

Toxin (Protein)


Gene name hicA Uniprot ID U9YXE2
Locus tag I6K19_RS04195 Protein ID WP_000833473.1
Coordinates 851396..851581 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID L4IWR9
Locus tag I6K19_RS04190 Protein ID WP_000499744.1
Coordinates 850969..851379 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K19_RS04175 (846481) 846481..847296 - 816 WP_000891825.1 AraC family transcriptional regulator -
I6K19_RS04180 (847522) 847522..848922 + 1401 WP_000204802.1 MFS transporter -
I6K19_RS04185 (848933) 848933..850897 + 1965 WP_001026861.1 glycoside hydrolase family 127 protein -
I6K19_RS04190 (850969) 850969..851379 - 411 WP_000499744.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
I6K19_RS04195 (851396) 851396..851581 - 186 WP_000833473.1 type II toxin-antitoxin system HicA family toxin Toxin
I6K19_RS04200 (851859) 851859..853397 - 1539 WP_001309845.1 aldehyde dehydrogenase AldB -
I6K19_RS04205 (853598) 853598..854749 - 1152 WP_000741501.1 L-threonine dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6800.89 Da        Isoelectric Point: 11.7053

>T192002 WP_000833473.1 NZ_CP069882:c851581-851396 [Escherichia coli]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

>T192002 NZ_CP092037:c1295708-1295514 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15241.15 Da        Isoelectric Point: 4.5486

>AT192002 WP_000499744.1 NZ_CP069882:c851379-850969 [Escherichia coli]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Download         Length: 411 bp

>AT192002 NZ_CP092037:1295337-1295515 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YXE2

Antitoxin

Source ID Structure
AlphaFold DB L4IWR9

References