Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 176519..177353 Replicon chromosome
Accession NZ_CP069882
Organism Escherichia coli strain FDAARGOS_1289

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H2VDB0
Locus tag I6K19_RS00900 Protein ID WP_000854688.1
Coordinates 176976..177353 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0H2VAY1
Locus tag I6K19_RS00895 Protein ID WP_001285596.1
Coordinates 176519..176899 (+) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K19_RS00860 (172804) 172804..173259 + 456 WP_000581502.1 IrmA family protein -
I6K19_RS00865 (173338) 173338..173571 + 234 WP_001119727.1 DUF905 family protein -
I6K19_RS00870 (173672) 173672..174490 + 819 WP_001234616.1 DUF932 domain-containing protein -
I6K19_RS00875 (174545) 174545..175030 + 486 WP_000849564.1 antirestriction protein -
I6K19_RS00880 (175046) 175046..175522 + 477 WP_001186726.1 RadC family protein -
I6K19_RS00885 (175585) 175585..175806 + 222 WP_000692329.1 DUF987 domain-containing protein -
I6K19_RS00890 (175825) 175825..176469 + 645 WP_000094917.1 hypothetical protein -
I6K19_RS00895 (176519) 176519..176899 + 381 WP_001285596.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6K19_RS00900 (176976) 176976..177353 + 378 WP_000854688.1 TA system toxin CbtA family protein Toxin
I6K19_RS00905 (177350) 177350..177838 + 489 WP_000761701.1 DUF5983 family protein -
I6K19_RS00910 (177855) 177855..178052 + 198 WP_000839260.1 DUF957 domain-containing protein -
I6K19_RS00915 (178266) 178266..179285 + 1020 WP_000875213.1 IS110 family transposase -
I6K19_RS00920 (179569) 179569..180414 + 846 WP_001280441.1 DUF4942 domain-containing protein -
I6K19_RS00925 (180483) 180483..180878 + 396 WP_000208383.1 DUF6088 family protein -
I6K19_RS00930 (180871) 180871..181805 + 935 Protein_186 nucleotidyl transferase AbiEii/AbiGii toxin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - kpsF / kpsE / kpsD / kpsU / kpsC / kpsS / kpsT / kpsM / gspM 176519..202113 25594


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14014.01 Da        Isoelectric Point: 8.5221

>T191999 WP_000854688.1 NZ_CP069882:176976-177353 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T191999 NZ_CP092037:c1161603-1161496 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13897.70 Da        Isoelectric Point: 4.7959

>AT191999 WP_001285596.1 NZ_CP069882:176519-176899 [Escherichia coli]
MSDTLPGTTLPDDNKDLPWWGLPCAVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT191999 NZ_CP092037:1161651-1161717 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2VDB0

Antitoxin

Source ID Structure
AlphaFold DB A0A0H2VAY1

References