Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4240611..4242199 Replicon chromosome
Accession NZ_CP069873
Organism Klebsiella pneumoniae strain FDAARGOS_1323

Toxin (Protein)


Gene name hipA Uniprot ID A0A9J6RYF8
Locus tag I6K53_RS20335 Protein ID WP_004892016.1
Coordinates 4240877..4242199 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag I6K53_RS20330 Protein ID WP_004176198.1
Coordinates 4240611..4240877 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K53_RS20305 4235640..4236563 + 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -
I6K53_RS20310 4236544..4237698 - 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
I6K53_RS20315 4238044..4239423 + 1380 WP_004184021.1 purine permease -
I6K53_RS20320 4239401..4239901 + 501 WP_032435339.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
I6K53_RS20325 4239898..4240224 + 327 WP_004184023.1 hydroxyisourate hydrolase -
I6K53_RS20330 4240611..4240877 + 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
I6K53_RS20335 4240877..4242199 + 1323 WP_004892016.1 type II toxin-antitoxin system HipA family toxin Toxin
I6K53_RS20340 4242216..4243508 - 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
I6K53_RS20345 4243650..4244654 - 1005 WP_032435338.1 type 1 fimbrial protein -
I6K53_RS20350 4244642..4247143 - 2502 WP_032435337.1 fimbrial biogenesis outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49141.44 Da        Isoelectric Point: 7.5357

>T191988 WP_004892016.1 NZ_CP069873:4240877-4242199 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T191988 NZ_CP092023:29965-30648 [Campylobacter jejuni subsp. jejuni]
ATGATTGATAAAGTTTTGAAATTTTTAGATGATGGTATTCCTAAAAATGATTTTGACAGACAACTTTTAGCTTCTAATTT
AGTAGGCGCAACAAATTTAATAGAGTTAAATAAACGAGAAAGAGAAATTACATTAAAAAAACAATTAAAACTACAACTCA
ATCCCATTAAAGGCAATTTCGATTATCAGCATTTAAAAGATATACATAAAGCACTTTTTGAAGATGTTTATACTTGGGCA
GGACAAGATAGAATGCAAATGGGACTAAAAGAAAAATTTGCAAAATATGCACCCAATGGAGCAATTATTAATTTTGTTCC
TGGAAAAGAGTTAGATAAATACTCTAAAATAATTTTTGATGAACTTGCAAAAAATAACTATCTAAAAAACTCCAAAGATC
TAAATCATTTTGCAAAAAATTTAGCAAAATTTATGGGCGAAATCAATGCTTTACACCCTTTTAGAGAAGGTAACGGCAGA
ACTCAAAGAATATTTTTAAACGAGTTGGCTAAAAATGCAGGTTATAAACTTGATTTAAATTTAATTTCTAAGCATAAAAT
GATACATGCTTGTGCAGAAGCTTCACAATTAAAACCTGGAAGATTGGAGGCTTTAATTAAAGACAATCTAAAAAACTTTA
GACAAAATTTAGATTTGGAGCAAAATAAAGGAATATCATTATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT191988 WP_004176198.1 NZ_CP069873:4240611-4240877 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT191988 NZ_CP092023:29730-29972 [Campylobacter jejuni subsp. jejuni]
ATGCAAAAACAATATCCCGAAGTGCATAGCTTAGAAGAAAGTCTTGCGATACTTAAAAAATATAAAGATGATTTAACTAA
AGAGCAATATGAAGGTATTAAATCTGTTATTTGCGGACACGCTATTGAAGATATGTTTGCAAATGAAAAAGATGTTATCG
ATATGATAAAAATTGCAAAAGATGAAGCAAATGCCGATGAAATAATCGCCGAATATAAAAGAGAATGGGGAGTAAATGAT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References