Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 4819626..4820152 | Replicon | chromosome |
| Accession | NZ_CP069865 | ||
| Organism | Escherichia coli strain FDAARGOS_1282 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | I6K12_RS23625 | Protein ID | WP_000323025.1 |
| Coordinates | 4819626..4819913 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | I6K12_RS23630 | Protein ID | WP_000534858.1 |
| Coordinates | 4819913..4820152 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6K12_RS23580 (4814650) | 4814650..4814865 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| I6K12_RS25660 (4815085) | 4815085..4815255 | + | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| I6K12_RS23585 (4815619) | 4815619..4815834 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| I6K12_RS23590 (4816135) | 4816135..4816347 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| I6K12_RS23595 (4816402) | 4816402..4816491 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| I6K12_RS23600 (4816769) | 4816769..4817521 | - | 753 | WP_001047135.1 | antitermination protein | - |
| I6K12_RS23605 (4817535) | 4817535..4818584 | - | 1050 | WP_001265199.1 | DUF968 domain-containing protein | - |
| I6K12_RS23610 (4818586) | 4818586..4818864 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| I6K12_RS23615 (4818931) | 4818931..4819182 | - | 252 | WP_000980994.1 | protein Rem | - |
| I6K12_RS23620 (4819399) | 4819399..4819554 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| I6K12_RS23625 (4819626) | 4819626..4819913 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| I6K12_RS23630 (4819913) | 4819913..4820152 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| I6K12_RS23635 (4820177) | 4820177..4820482 | + | 306 | WP_001326990.1 | protein YdfV | - |
| I6K12_RS23640 (4820685) | 4820685..4821017 | + | 333 | WP_001301033.1 | FlxA-like family protein | - |
| I6K12_RS25875 (4821454) | 4821454..4821603 | - | 150 | WP_011443592.1 | protein YdfW | - |
| I6K12_RS23645 (4821676) | 4821676..4822746 | - | 1071 | Protein_4512 | ISNCY family transposase | - |
| I6K12_RS23650 (4823251) | 4823251..4824273 | - | 1023 | WP_000915483.1 | DUF4868 domain-containing protein | - |
| I6K12_RS23655 (4824276) | 4824276..4824890 | - | 615 | WP_001265627.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 4784019..4834670 | 50651 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T191977 WP_000323025.1 NZ_CP069865:c4819913-4819626 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T191977 NZ_CP092012:4187922-4188338 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGAGTAAAACCTACATGCTGGATACCTGCATCTGTTCTTTCATTATGCGCGAACAGCCGGAAGCTGTGCTGAAACGCCT
TGAGCAGGCAGTGCTGCGCCGCCATCGTATTGTGGTGTCGGCGATTACCTACGCCGAAATGCGTTTTGGCTGTACGGGCA
AAAAGGCCTCGCCGCGCCATGCCCAACTGGTCGATGCATTCTGTAGTCGCCTGGATGCCGTGCTGGCCTGGGACCGGGCG
GCAGTGGATGCCACCACAGAGATCCGTGCCGTACTGGCCGCCGCCGGTACGCCGATTGGATCAAACGATGCTGCTATCGC
CGGCCATGCCATTGCGTCCGGGGCGATACTGGTCACTAATAACGTGAGGGAGTTTGAGCGGGTACCGGGTTTGCAGTACG
AAGATTGGGTAAAATAA
ATGAGTAAAACCTACATGCTGGATACCTGCATCTGTTCTTTCATTATGCGCGAACAGCCGGAAGCTGTGCTGAAACGCCT
TGAGCAGGCAGTGCTGCGCCGCCATCGTATTGTGGTGTCGGCGATTACCTACGCCGAAATGCGTTTTGGCTGTACGGGCA
AAAAGGCCTCGCCGCGCCATGCCCAACTGGTCGATGCATTCTGTAGTCGCCTGGATGCCGTGCTGGCCTGGGACCGGGCG
GCAGTGGATGCCACCACAGAGATCCGTGCCGTACTGGCCGCCGCCGGTACGCCGATTGGATCAAACGATGCTGCTATCGC
CGGCCATGCCATTGCGTCCGGGGCGATACTGGTCACTAATAACGTGAGGGAGTTTGAGCGGGTACCGGGTTTGCAGTACG
AAGATTGGGTAAAATAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT191977 WP_000534858.1 NZ_CP069865:c4820152-4819913 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT191977 NZ_CP092012:4187695-4187925 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGCGAACCGTATCTGTATTTAAAAATGGCAATAACCGCGCGATCCGCCTTCCACGCGATCTGGATTTTGACGGCGTCAA
CGAACTTGAAATCTTCCGCGAAGGCGACACGATTATACTGCGCCCCGCCCGCCCTTCCTGGGGATCATTCCGTCATGAGG
AAAAAGCCAGCCCAGACTTTCTGACGGAACGCGAAGACATCATCAGCGATGAGGGACGCTTTGAACTATGA
ATGCGAACCGTATCTGTATTTAAAAATGGCAATAACCGCGCGATCCGCCTTCCACGCGATCTGGATTTTGACGGCGTCAA
CGAACTTGAAATCTTCCGCGAAGGCGACACGATTATACTGCGCCCCGCCCGCCCTTCCTGGGGATCATTCCGTCATGAGG
AAAAAGCCAGCCCAGACTTTCTGACGGAACGCGAAGACATCATCAGCGATGAGGGACGCTTTGAACTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|