Detailed information of TA system TA191964

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 2859879..2860693
• Replicon: chromosome
• Accession: NZ_CP069865
• Organism: Escherichia coli strain FDAARGOS_1282

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: I6K12_RS14230
• Protein ID: WP_001054376.1
• Coordinates: 2860436..2860693 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: I6K12_RS14225
• Protein ID: WP_001309181.1
• Coordinates: 2859879..2860424 (-)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K12_RS14195 (2855570)	2855570..2856883	-	1314	WP_000460843.1	PTS sugar transporter subunit IIC SgcC	-
I6K12_RS14200 (2856895)	2856895..2857173	-	279	WP_000722973.1	PTS sugar transporter subunit IIB SgcB	-
I6K12_RS14205 (2857170)	2857170..2858291	-	1122	WP_000010829.1	M42 family metallopeptidase	-
I6K12_RS14210 (2858536)	2858536..2858652	-	117	Protein_2648	VOC family protein	-
I6K12_RS14215 (2858690)	2858690..2858908	-	219	Protein_2649	hypothetical protein	-
I6K12_RS14220 (2859077)	2859077..2859823	-	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
I6K12_RS14225 (2859879)	2859879..2860424	-	546	WP_001309181.1	N-acetyltransferase	Antitoxin
I6K12_RS14230 (2860436)	2860436..2860693	-	258	WP_001054376.1	YjhX family toxin	Toxin
I6K12_RS25775 (2861184)	2861184..2861315	-	132	WP_001309182.1	hypothetical protein	-
I6K12_RS14240 (2861431)	2861431..2862671	+	1241	Protein_2654	helicase YjhR	-
I6K12_RS25780 (2862939)	2862939..2863144	-	206	Protein_2655	HNH endonuclease	-
I6K12_RS14245 (2863254)	2863254..2864234	-	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
I6K12_RS14250 (2864299)	2864299..2865405	-	1107	WP_001309184.1	N-acetylneuraminate epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T191964 WP_001054376.1 NZ_CP069865:c2860693-2860436 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T191964 NZ_CP092009:3620142-3620399 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGAATGCCTCCGGCGCCAGCGTCCGCCACATCAACAGCGAAACCTGCATGACCACCAGTTACTCACATATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTAAGACCGGGCGCGGCGTCACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAACAGCTTTACAAGGCTGAACAGGTGGTTAAGGGGATG
CGGGACGTGATTGTTTAG

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT191964 WP_001309181.1 NZ_CP069865:c2860424-2859879 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT191964 NZ_CP092009:c3620317-3619985 [Salmonella enterica subsp. enterica serovar Kentucky]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGG
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTTAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8