191962

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 2741768..2742363 Replicon chromosome
Accession NZ_CP069865
Organism Escherichia coli strain FDAARGOS_1282

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag I6K12_RS13645 Protein ID WP_000239581.1
Coordinates 2742013..2742363 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag I6K12_RS13640 Protein ID WP_001223213.1
Coordinates 2741768..2742019 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K12_RS13630 (2737433) 2737433..2741212 + 3780 WP_001522396.1 autotransporter assembly complex protein TamB -
I6K12_RS13635 (2741215) 2741215..2741556 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
I6K12_RS13640 (2741768) 2741768..2742019 + 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
I6K12_RS13645 (2742013) 2742013..2742363 + 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
I6K12_RS13650 (2742442) 2742442..2742972 - 531 WP_000055075.1 inorganic diphosphatase -
I6K12_RS13655 (2743282) 2743282..2744238 + 957 WP_001522398.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
I6K12_RS13660 (2744371) 2744371..2745873 + 1503 WP_001522399.1 sugar ABC transporter ATP-binding protein -
I6K12_RS13665 (2745887) 2745887..2746909 + 1023 WP_001361374.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T191962 WP_000239581.1 NZ_CP069865:2742013-2742363 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

>T191962 NZ_CP092009:2429455-2429739 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAGTGACACGACACAGAAGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT191962 WP_001223213.1 NZ_CP069865:2741768-2742019 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT191962 NZ_CP092009:2429217-2429465 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGACCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGTAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References