Detailed information of TA system
Overview
TA module
| Type | V | Classification (family/domain) | ghoTS/ghoT-GhoS |
| Location | 2644317..2644814 | Replicon | chromosome |
| Accession | NZ_CP069865 | ||
| Organism | Escherichia coli strain FDAARGOS_1282 | ||
Toxin (Protein)
| Gene name | ghoT | Uniprot ID | L4JJG6 |
| Locus tag | I6K12_RS13140 | Protein ID | WP_001173343.1 |
| Coordinates | 2644641..2644814 (+) | Length | 58 a.a. |
Antitoxin (Protein)
| Gene name | ghoS | Uniprot ID | L4JK92 |
| Locus tag | I6K12_RS13135 | Protein ID | WP_000398619.1 |
| Coordinates | 2644317..2644613 (+) | Length | 99 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6K12_RS13115 (2641046) | 2641046..2641765 | - | 720 | WP_000611288.1 | two-component system response regulator DcuR | - |
| I6K12_RS13120 (2641762) | 2641762..2643393 | - | 1632 | WP_001216477.1 | sensor histidine kinase | - |
| I6K12_RS13125 (2643574) | 2643574..2643804 | + | 231 | WP_000373291.1 | 4Fe-4S mono-cluster protein YjdI | - |
| I6K12_RS13130 (2643816) | 2643816..2644088 | + | 273 | WP_000405647.1 | GNAT family N-acetyltransferase | - |
| I6K12_RS13135 (2644317) | 2644317..2644613 | + | 297 | WP_000398619.1 | type V toxin-antitoxin system endoribonuclease antitoxin GhoS | Antitoxin |
| I6K12_RS13140 (2644641) | 2644641..2644814 | + | 174 | WP_001173343.1 | type V toxin-antitoxin system toxin GhoT | Toxin |
| I6K12_RS13145 (2644933) | 2644933..2646450 | - | 1518 | WP_000003806.1 | lysine--tRNA ligase | - |
| I6K12_RS13150 (2646687) | 2646687..2648144 | - | 1458 | WP_000856827.1 | dipeptide/tripeptide permease DtpC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 58 a.a. Molecular weight: 6555.06 Da Isoelectric Point: 10.2288
>T191961 WP_001173343.1 NZ_CP069865:2644641-2644814 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF
Download Length: 174 bp
>T191961 NZ_CP092009:2062739-2062842 [Salmonella enterica subsp. enterica serovar Kentucky]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT
Antitoxin
Download Length: 99 a.a. Molecular weight: 11467.97 Da Isoelectric Point: 4.1705
>AT191961 WP_000398619.1 NZ_CP069865:2644317-2644613 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK
Download Length: 297 bp
>AT191961 NZ_CP092009:c2062844-2062701 [Salmonella enterica subsp. enterica serovar Kentucky]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U9QI41 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U9QBH6 |