191957

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1307884..1308538 Replicon chromosome
Accession NZ_CP069865
Organism Escherichia coli strain FDAARGOS_1282

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag I6K12_RS06870 Protein ID WP_000244781.1
Coordinates 1307884..1308291 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag I6K12_RS06875 Protein ID WP_000354046.1
Coordinates 1308272..1308538 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K12_RS06850 (1303841) 1303841..1305574 - 1734 WP_000813232.1 single-stranded-DNA-specific exonuclease RecJ -
I6K12_RS06855 (1305580) 1305580..1306290 - 711 WP_000715223.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I6K12_RS06860 (1306315) 1306315..1307211 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
I6K12_RS06865 (1307323) 1307323..1307844 + 522 WP_001055874.1 flavodoxin FldB -
I6K12_RS06870 (1307884) 1307884..1308291 - 408 WP_000244781.1 protein YgfX Toxin
I6K12_RS06875 (1308272) 1308272..1308538 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
I6K12_RS06880 (1308790) 1308790..1309770 + 981 WP_000886102.1 tRNA-modifying protein YgfZ -
I6K12_RS06885 (1309966) 1309966..1310625 - 660 WP_000250283.1 hemolysin III family protein -
I6K12_RS06890 (1310789) 1310789..1311100 - 312 WP_001182943.1 N(4)-acetylcytidine aminohydrolase -
I6K12_RS06895 (1311145) 1311145..1312578 + 1434 WP_001605840.1 6-phospho-beta-glucosidase BglA -
I6K12_RS06900 (1312635) 1312635..1313378 - 744 WP_000951966.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T191957 WP_000244781.1 NZ_CP069865:c1308291-1307884 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T191957 NZ_CP092009:195438-195923 [Salmonella enterica subsp. enterica serovar Kentucky]
GTGGGACATGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCAACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGAAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT191957 WP_000354046.1 NZ_CP069865:c1308538-1308272 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT191957 NZ_CP092009:195163-195450 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References