Detailed information of TA system TA191942

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 179765..180675
• Replicon: plasmid unnamed2
• Accession: NZ_CP069863
• Organism: Klebsiella pneumoniae strain FDAARGOS_1311

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A2A5MBW7
• Locus tag: I6K41_RS27085
• Protein ID: WP_023329005.1
• Coordinates: 180205..180675 (+)
• Length: 157 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: I6K41_RS27080
• Protein ID: WP_023329004.1
• Coordinates: 179765..180208 (+)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K41_RS27055	175549..175887	-	339	WP_032738440.1	hypothetical protein	-
I6K41_RS27060	176086..176807	+	722	Protein_181	DUF969 domain-containing protein	-
I6K41_RS27065	176804..177790	+	987	Protein_182	DUF979 domain-containing protein	-
I6K41_RS27070	177800..178795	+	996	WP_032738441.1	DUF2891 domain-containing protein	-
I6K41_RS27075	178956..179643	+	688	Protein_184	DUF4113 domain-containing protein	-
I6K41_RS27080	179765..180208	+	444	WP_023329004.1	DUF2384 domain-containing protein	Antitoxin
I6K41_RS27085	180205..180675	+	471	WP_023329005.1	RES family NAD+ phosphorylase	Toxin
I6K41_RS27090	180786..181045	-	260	Protein_187	hypothetical protein	-
I6K41_RS27095	181847..183190	+	1344	WP_032738442.1	ISNCY family transposase	-
I6K41_RS27100	183206..183490	-	285	WP_004187019.1	type II toxin-antitoxin system RelE/ParE family toxin	-
I6K41_RS27105	183480..183728	-	249	WP_004187025.1	plasmid stabilization protein	-
I6K41_RS27110	184016..184984	+	969	WP_204745803.1	IS5 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	pla	1..204513	204513
	-	flank	IS/Tn	-	-	184016..184984	968

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (94-144)

Sequences

Toxin

Protein

• Length: 157 a.a.
• Molecular weight: 17459.70 Da
• Isoelectric Point: 4.4829

>T191942 WP_023329005.1 NZ_CP069863:180205-180675 [Klebsiella pneumoniae]
VILYRLTKTKNLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPANWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHSDFYGIVQMAQQIPFRFDSRLKPDRK

Nucleotide

• Length: 471 bp

>T191942 NZ_CP091999:c4263516-4263025 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGATCTCCTCCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATGGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGTGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCGCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGATTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTTGGTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTACCAGCGGGTGGGGTTTGAACCATCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16477.82 Da
• Isoelectric Point: 10.2498

>AT191942 WP_023329004.1 NZ_CP069863:179765-180208 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADSVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAALKWLNEPNRALSWKVPADLIASETGAYEVIKLITRLEHGVYS

Nucleotide

• Length: 444 bp

>AT191942 NZ_CP091999:c4263806-4263513 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGTCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATCGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCACAGGCTTATCAGGAATTTCTGGCTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Structures

Toxin

• AlphaFold DB: A0A2A5MBW7