Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2463211..2463830 Replicon chromosome
Accession NZ_CP069861
Organism Klebsiella pneumoniae strain FDAARGOS_1311

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag I6K41_RS11875 Protein ID WP_002892050.1
Coordinates 2463211..2463429 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag I6K41_RS11880 Protein ID WP_002892066.1
Coordinates 2463456..2463830 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K41_RS11840 2459258..2459521 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
I6K41_RS11845 2459521..2459661 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
I6K41_RS11850 2459658..2460356 - 699 WP_002892021.1 GNAT family N-acetyltransferase -
I6K41_RS11855 2460457..2461908 + 1452 WP_023302231.1 PLP-dependent aminotransferase family protein -
I6K41_RS11860 2461883..2462353 - 471 WP_002892026.1 YlaC family protein -
I6K41_RS11865 2462374..2462514 + 141 WP_004147370.1 hypothetical protein -
I6K41_RS11870 2462486..2463052 - 567 WP_002892030.1 maltose O-acetyltransferase -
I6K41_RS11875 2463211..2463429 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
I6K41_RS11880 2463456..2463830 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
I6K41_RS11885 2464316..2467462 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
I6K41_RS11890 2467485..2468678 - 1194 WP_204745782.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T191932 WP_002892050.1 NZ_CP069861:c2463429-2463211 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T191932 NZ_CP091998:4726698-4727114 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGAGTAAAACCTACATGCTGGATACCTGCATCTGTTCTTTCATTATGCGCGAACAGCCGGAAGCTGTGCTGAAACGCCT
TGAGCAGGCAGTGCTGCGCCGCCATCGTATTGTGGTGTCGGCGATTACCTACGCCGAAATGCGTTTTGGCTGTACGGGCA
AAAAGGCCTCGCCGCGCCATGCCCAACTGGTCGATGCATTCTGTAGTCGCCTGGATGCCGTGCTGGCCTGGGACCGGGCG
GCAGTGGATGCCACCACAGAGATCCGTGCCGTACTGGCCGCCGCCGGTACGCCGATTGGATCAAACGATGCTGCTATCGC
CGGCCATGCCATTGCGTCCGGGGCGATACTGGTCACTAATAACGTGAGGGAGTTTGAGCGGGTACCGGGTTTGCAGTACG
AAGATTGGGTAAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT191932 WP_002892066.1 NZ_CP069861:c2463830-2463456 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT191932 NZ_CP091998:4726471-4726701 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGCGAACCGTATCTGTATTTAAAAATGGCAATAACCGCGCGATCCGCCTTCCACGCGATCTGGATTTTGACGGCGTCAA
CGAACTTGAAATCTTCCGCGAAGGCGACACGATTATACTGCGCCCCGCCCGCCCTTCCTGGGGATCATTCCGTCATGAGG
AAAAAGCCAGCCCAGACTTTCTGACGGAACGCGAAGACATCATCAGCGATGAGGGACGCTTTGAACTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References