Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1709747..1710263 Replicon chromosome
Accession NZ_CP069861
Organism Klebsiella pneumoniae strain FDAARGOS_1311

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag I6K41_RS08370 Protein ID WP_002886902.1
Coordinates 1709979..1710263 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag I6K41_RS08365 Protein ID WP_002886901.1
Coordinates 1709747..1709989 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K41_RS08350 1705775..1706515 + 741 WP_002886899.1 KDGP aldolase family protein -
I6K41_RS08355 1706582..1707736 + 1155 WP_023302389.1 lactonase family protein -
I6K41_RS08360 1707759..1709669 + 1911 WP_009486549.1 BglG family transcription antiterminator -
I6K41_RS08365 1709747..1709989 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I6K41_RS08370 1709979..1710263 + 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6K41_RS08375 1710267..1710731 - 465 WP_023302390.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
I6K41_RS08380 1711040..1713178 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
I6K41_RS08385 1713535..1714278 - 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
I6K41_RS08390 1714281..1714454 - 174 WP_032410138.1 hypothetical protein -
I6K41_RS08395 1714539..1714847 + 309 WP_012737232.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T191930 WP_002886902.1 NZ_CP069861:1709979-1710263 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T191930 NZ_CP091998:c4456356-4456045 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGATCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT191930 WP_002886901.1 NZ_CP069861:1709747-1709989 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT191930 NZ_CP091998:c4456044-4455754 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTAAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGCTCACCGACAGGGCCAGCCAAAGCATTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References