Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1654421..1655078 Replicon chromosome
Accession NZ_CP069853
Organism Klebsiella pneumoniae strain FDAARGOS_1324

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag I6K54_RS08125 Protein ID WP_002916310.1
Coordinates 1654668..1655078 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag I6K54_RS08120 Protein ID WP_002916312.1
Coordinates 1654421..1654687 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K54_RS08095 1649578..1651011 - 1434 WP_004174453.1 6-phospho-beta-glucosidase -
I6K54_RS08100 1651130..1651858 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
I6K54_RS08105 1651908..1652219 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
I6K54_RS08110 1652383..1653042 + 660 WP_002916317.1 hemolysin III family protein -
I6K54_RS08115 1653192..1654175 - 984 WP_004185555.1 tRNA-modifying protein YgfZ -
I6K54_RS08120 1654421..1654687 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
I6K54_RS08125 1654668..1655078 + 411 WP_002916310.1 protein YgfX Toxin
I6K54_RS08130 1655085..1655606 - 522 WP_004144730.1 flavodoxin FldB -
I6K54_RS08135 1655707..1656603 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
I6K54_RS08140 1656626..1657339 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I6K54_RS08145 1657345..1659078 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T191910 WP_002916310.1 NZ_CP069853:1654668-1655078 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T191910 NZ_CP091992:5260227-5260511 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT191910 WP_002916312.1 NZ_CP069853:1654421-1654687 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT191910 NZ_CP091992:5259995-5260237 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References