Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3398069..3398720 Replicon chromosome
Accession NZ_CP069851
Organism Acinetobacter baumannii strain FDAARGOS_1359

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag I6K89_RS16280 Protein ID WP_000838146.1
Coordinates 3398069..3398251 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1AAF8
Locus tag I6K89_RS16285 Protein ID WP_000966689.1
Coordinates 3398316..3398720 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K89_RS16235 3393326..3393991 + 666 WP_000767881.1 stress-responsive nuclear envelope protein -
I6K89_RS16240 3393996..3394385 + 390 WP_000008492.1 hypothetical protein -
I6K89_RS16245 3394387..3394755 + 369 WP_000524231.1 hypothetical protein -
I6K89_RS16250 3394764..3395168 + 405 WP_000248323.1 hypothetical protein -
I6K89_RS16255 3395140..3395508 + 369 WP_000539752.1 hypothetical protein -
I6K89_RS16260 3395510..3395908 + 399 WP_001132270.1 hypothetical protein -
I6K89_RS16265 3395910..3396122 + 213 WP_000121166.1 hypothetical protein -
I6K89_RS16270 3396230..3397159 + 930 WP_000094299.1 hypothetical protein -
I6K89_RS16275 3397204..3397737 + 534 WP_001185622.1 hypothetical protein -
I6K89_RS16280 3398069..3398251 + 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
I6K89_RS16285 3398316..3398720 + 405 WP_000966689.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
I6K89_RS16290 3398801..3399202 + 402 WP_000720591.1 hypothetical protein -
I6K89_RS16295 3399263..3403228 + 3966 WP_000191304.1 tape measure protein -
I6K89_RS16300 3403346..3403687 + 342 WP_001281459.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3363694..3423380 59686


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T191902 WP_000838146.1 NZ_CP069851:3398069-3398251 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T191902 NZ_CP091992:c675302-675084 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14769.78 Da        Isoelectric Point: 4.5000

>AT191902 WP_000966689.1 NZ_CP069851:3398316-3398720 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT191902 NZ_CP091992:c675703-675329 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1AAF8

References