Detailed information of TA system TA191901

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 2834288..2834941
• Replicon: chromosome
• Accession: NZ_CP069851
• Organism: Acinetobacter baumannii strain FDAARGOS_1359

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: I6K89_RS13600
• Protein ID: WP_000607077.1
• Coordinates: 2834552..2834941 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: I6K89_RS13595
• Protein ID: WP_001288210.1
• Coordinates: 2834288..2834545 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K89_RS13575	2829804..2830811	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
I6K89_RS13580	2830830..2831207	+	378	WP_001216380.1	50S ribosomal protein L17	-
I6K89_RS13585	2831389..2832879	+	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
I6K89_RS13590	2832928..2834100	-	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
I6K89_RS13595	2834288..2834545	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
I6K89_RS13600	2834552..2834941	+	390	WP_000607077.1	membrane protein	Toxin
I6K89_RS13605	2835711..2836796	+	1086	WP_000049106.1	hypothetical protein	-
I6K89_RS13610	2836874..2837440	+	567	WP_000651538.1	rhombosortase	-
I6K89_RS13615	2837628..2839823	+	2196	WP_001158906.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T191901 WP_000607077.1 NZ_CP069851:2834552-2834941 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T191901 NZ_CP091992:61282-61815 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT191901 WP_001288210.1 NZ_CP069851:2834288-2834545 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT191901 NZ_CP091992:61005-61271 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7