Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4194221..4194878 Replicon chromosome
Accession NZ_CP069847
Organism Klebsiella pneumoniae strain FDAARGOS_1305

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag I6K35_RS22485 Protein ID WP_002916310.1
Coordinates 4194468..4194878 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag I6K35_RS22480 Protein ID WP_002916312.1
Coordinates 4194221..4194487 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K35_RS22455 4189429..4190862 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
I6K35_RS22460 4190981..4191709 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
I6K35_RS22465 4191759..4192070 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
I6K35_RS22470 4192234..4192893 + 660 WP_002916317.1 hemolysin III family protein -
I6K35_RS22475 4192992..4193975 - 984 WP_023286864.1 tRNA-modifying protein YgfZ -
I6K35_RS22480 4194221..4194487 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
I6K35_RS22485 4194468..4194878 + 411 WP_002916310.1 protein YgfX Toxin
I6K35_RS22490 4194885..4195406 - 522 WP_004144730.1 flavodoxin FldB -
I6K35_RS22495 4195507..4196403 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
I6K35_RS22500 4196426..4197139 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I6K35_RS22505 4197145..4198878 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T191900 WP_002916310.1 NZ_CP069847:4194468-4194878 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T191900 NZ_CP091987:55121-55603 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT191900 WP_002916312.1 NZ_CP069847:4194221-4194487 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT191900 NZ_CP091987:54867-55133 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References