Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2841591..2842107 Replicon chromosome
Accession NZ_CP069847
Organism Klebsiella pneumoniae strain FDAARGOS_1305

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag I6K35_RS15910 Protein ID WP_004178374.1
Coordinates 2841591..2841875 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag I6K35_RS15915 Protein ID WP_002886901.1
Coordinates 2841865..2842107 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K35_RS15885 2837067..2837375 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
I6K35_RS15890 2837460..2837633 + 174 Protein_2726 hypothetical protein -
I6K35_RS15895 2837636..2838379 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
I6K35_RS15900 2838736..2840874 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
I6K35_RS15905 2841123..2841587 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
I6K35_RS15910 2841591..2841875 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6K35_RS15915 2841865..2842107 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I6K35_RS15920 2842185..2844095 - 1911 WP_064278334.1 BglG family transcription antiterminator -
I6K35_RS15925 2844118..2845272 - 1155 WP_004178372.1 lactonase family protein -
I6K35_RS15930 2845339..2846079 - 741 WP_087848438.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T191895 WP_004178374.1 NZ_CP069847:c2841875-2841591 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T191895 NZ_CP091983:1552076-1552414 [Burkholderia vietnamiensis]
ATGGTTGACATATCGAGTAACGTGCCTTACAGTGCTCCGACGTACAGCATCAGAACGACCGAAGTCTTCGACACATGGTT
CGCCGGTCTGCAGGATCGCGTCGCACGGCGGCGTATCCAGGCCCGCATCGACCGCCTGTCGATGGGCAATCCGGGCGACT
GGAAGTCGGCCGGCTCCCCGGTCGTCGAGATGCGTATCGACCACGGCCCCGGCTATCGCGTCTACTACGTCAGGCGCGCG
ACGATCTGGGTGATCCTGCTCTGCGGCGGCGACAAGTCGACGCAACAGGCAGACATTCGCGCCGCGCACGCAATGCTCGG
GCGGCTCGACCTGGAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT191895 WP_002886901.1 NZ_CP069847:c2842107-2841865 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT191895 NZ_CP091983:1552418-1552717 [Burkholderia vietnamiensis]
ATGGACAAGATCAGCACCCGGCCGTGGGATTCGGCCGCCCACCTCGAAACCGACGACGACATCGCCGACTATTTCGACGC
GTGCCTGCAGGAAGGCGGCGACGACCCGGCCTTCATCGCGCATGCGCTCGGCGTGATCGCGCGCGCGCGCGGCATGTCGC
AGGTCGCCCGCGACGCCGGCCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAATCCGAGCTTCGGCACG
ATCCTCAAAGTGATCAAGGCGCTCGGCCTGCAACTGCACGGCGCGAAAGCGCGCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References