Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 735641..737229 Replicon chromosome
Accession NZ_CP069847
Organism Klebsiella pneumoniae strain FDAARGOS_1305

Toxin (Protein)


Gene name hipA Uniprot ID A0A8E1ZGL5
Locus tag I6K35_RS05775 Protein ID WP_048270684.1
Coordinates 735641..736963 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag I6K35_RS05780 Protein ID WP_004176198.1
Coordinates 736963..737229 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K35_RS05760 730697..733198 + 2502 WP_204752580.1 fimbria/pilus outer membrane usher protein -
I6K35_RS05765 733186..734190 + 1005 WP_040165992.1 type 1 fimbrial protein -
I6K35_RS05770 734332..735624 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
I6K35_RS05775 735641..736963 - 1323 WP_048270684.1 type II toxin-antitoxin system HipA family toxin Toxin
I6K35_RS05780 736963..737229 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
I6K35_RS05785 737494..737820 - 327 WP_004143476.1 hydroxyisourate hydrolase -
I6K35_RS05790 737817..738317 - 501 WP_004190169.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
I6K35_RS05795 738295..739674 - 1380 WP_004184021.1 purine permease -
I6K35_RS05800 740020..741174 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
I6K35_RS05805 741155..742078 - 924 WP_004184020.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - mgtC / iroE 564809..772711 207902


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49155.46 Da        Isoelectric Point: 7.5358

>T191891 WP_048270684.1 NZ_CP069847:c736963-735641 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T191891 NZ_CP091978:c4503699-4503597 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT191891 WP_004176198.1 NZ_CP069847:c737229-736963 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT191891 NZ_CP091978:4503590-4503735 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References