Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 118103..118755 Replicon plasmid unnamed3
Accession NZ_CP069846
Organism Klebsiella pneumoniae strain FDAARGOS_1305

Toxin (Protein)


Gene name vagD Uniprot ID A0A8A2Q2K1
Locus tag I6K35_RS01315 Protein ID WP_017901321.1
Coordinates 118330..118755 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A853H7M9
Locus tag I6K35_RS01310 Protein ID WP_001261275.1
Coordinates 118103..118333 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K35_RS01305 115274..117850 + 2577 WP_017901322.1 EstP -
I6K35_RS01310 118103..118333 + 231 WP_001261275.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
I6K35_RS01315 118330..118755 + 426 WP_017901321.1 type II toxin-antitoxin system VapC family toxin Toxin
I6K35_RS01320 118773..119741 + 969 WP_077254762.1 IS5 family transposase -
I6K35_RS01325 119776..120336 + 561 Protein_117 transposase -
I6K35_RS01330 120734..122305 + 1572 WP_049257520.1 sensor domain-containing diguanylate cyclase -
I6K35_RS01335 122397..122510 - 114 WP_077252861.1 IS3 family transposase -
I6K35_RS01340 122635..122805 + 171 Protein_120 LysR family transcriptional regulator -
I6K35_RS01345 122930..123046 - 117 Protein_121 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..241224 241224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15412.91 Da        Isoelectric Point: 7.1364

>T191878 WP_017901321.1 NZ_CP069846:118330-118755 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQVVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPGLVLEDWVGFVE

Download         Length: 426 bp

>T191878 NZ_CP091977:3977515-3978009 [Aromatoleum aromaticum]
ATGAGCTTGCAACTGAGCGCACCGCAACCCCTCGCTGCCACTCATCTTCTGGATGAATTTGCCAGCGGAGAAACGTGTCT
GGACGAATGGCTCAAGCGGCGGGCGCTGTCCAATCAGTTGAGTGGAGCCAGCCGCACATTCGTCGTCACGGATCAGGAGC
AGCACGTTTTCGGCTACTACGCGATGGCGGCCGGAGCGGTCTCGCACCAGATGGCGACGGGCGGCGTGCGGCGAAACATG
CCTGACCCCATTCCGGTGATGGTGCTGGCACGGCTCGCTATTGACGATCGTGTCCAGGGCATCAAACTCGGAGCCGCCCT
GCTTCAAGACGCTGTCAATCGGGCCGTGGCAGTGTCGCAGAACGCGGGCGTGCGAGCCTTGCTCGTTCATGCGCTTCACG
AGCATGCCAAGCAGTTTTACGAGCACTACGGTTTTCAGGAATCGCCACAGCACCCGATGACGCTGATGCTGCGCCTGAAC
ACCGTCAAGGCTTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8707.72 Da        Isoelectric Point: 4.3410

>AT191878 WP_001261275.1 NZ_CP069846:118103-118333 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFDP

Download         Length: 231 bp

>AT191878 NZ_CP091977:3977246-3977518 [Aromatoleum aromaticum]
ATGCGTGACGCGGCCATCAACCTGCGGGCCTTGCCCGAGCAGCGTGACCTGATCGATCACGCTGCCAGCCTGTTGGGCAA
GAACCGTTCGGACTTCATGCTCGAAGCTGCTTGCGACCGAGCACAGGCCGTGGTGCTGGATCAGGTCTTTTTTGGCCTGG
ACGCCGACAAGTTCAAGCAGTTCACTGCCATGCTGGACGCACCCCCTGGACCAAATCCCGGGCTTGAACGCCTCATGGCC
GTGCAGGCGCCGTGGCGCACCGGCGCGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8A2Q2K1

Antitoxin

Source ID Structure
AlphaFold DB A0A853H7M9

References