Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 2913..3501 Replicon plasmid unnamed2
Accession NZ_CP069842
Organism Acinetobacter baumannii strain FDAARGOS_1360

Toxin (Protein)


Gene name brnT Uniprot ID A0A0J8TIH5
Locus tag I6K90_RS19635 Protein ID WP_000438827.1
Coordinates 2913..3200 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag I6K90_RS19640 Protein ID WP_001983304.1
Coordinates 3187..3501 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K90_RS19615 453..1403 + 951 WP_001205343.1 replication initiation protein RepM -
I6K90_RS19620 1396..1971 + 576 WP_001096616.1 helix-turn-helix domain-containing protein -
I6K90_RS19625 1991..2134 + 144 WP_001125244.1 hypothetical protein -
I6K90_RS19630 2319..2522 - 204 WP_000482656.1 hypothetical protein -
I6K90_RS19635 2913..3200 + 288 WP_000438827.1 BrnT family toxin Toxin
I6K90_RS19640 3187..3501 + 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
I6K90_RS19645 3629..6040 + 2412 WP_000932953.1 TonB-dependent receptor ZnuD2 -
I6K90_RS19650 6345..6806 + 462 WP_000761346.1 DIP1984 family protein -
I6K90_RS19655 7163..8328 - 1166 Protein_8 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..14879 14879


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11329.75 Da        Isoelectric Point: 5.6762

>T191875 WP_000438827.1 NZ_CP069842:2913-3200 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRYTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

>T191875 NZ_CP091977:2877794-2878204 [Aromatoleum aromaticum]
ATGTCGGTCCGCTATTTGCTCGACACGAACATCTGCATCTACATCGCGAAGCACAACCCGCCGGAAGTTCGCCAGCGCTT
CGCCCGCCACGCTGCATCCGAACTCGCGATGTCCGTCATCACGCTCGGCGAACTGCGCTTCGGCGCGGAGAAGAGCCAGG
CCCGCGACAAGGCGCTCGCTGCGATTCAAAGGCTGGAAGCGACGGTCCGGATCGCGCCACTGACGGAGTCGGTCGGCGAG
CACTACGGCCAGATCCGCGCGAATCTCCAGCACAAGGGCCAACCGATCGGCAACAACGACCTGTGGCTGGCCGCCCACGC
GCGCGCCGAAGGTTGGATCCTCGTGACAAACAACGAACGCGAATTCGTCCGCGTAGAAGGACTGCAAGTCGAAAACTGGG
TAGACCGATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT191875 WP_001983304.1 NZ_CP069842:3187-3501 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp

>AT191875 NZ_CP091977:2877563-2877793 [Aromatoleum aromaticum]
ATGGTTTACGCCCGCGTCTTCCGCTCCGGCAACAGCCAGGCGGTCCGCCTGCCGAAGGAGTTTCGGCTCGATACGGACCG
GGTCGAAATCTTCCGCCGCGGCGATGAAATCGTGCTGCGCGAACTGCCCGGCAATGCGGCCGCGATTTTCGATGCGCTAA
TCGAGCTGCCCGTCAACTTCATGTCTGAAGGGCGCAACGATGTCGCGCCACAGGAGCGGGAGGCGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J8TIH5

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References