Detailed information of TA system TA191874

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 2322683..2323336
• Replicon: chromosome
• Accession: NZ_CP069840
• Organism: Acinetobacter baumannii strain FDAARGOS_1360

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: I6K90_RS11195
• Protein ID: WP_000607077.1
• Coordinates: 2322683..2323072 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: I6K90_RS11200
• Protein ID: WP_001288210.1
• Coordinates: 2323079..2323336 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K90_RS11180	2317801..2319996	-	2196	WP_001158906.1	TRAP transporter large permease subunit	-
I6K90_RS11185	2320184..2320750	-	567	WP_000651538.1	rhombosortase	-
I6K90_RS11190	2320828..2321913	-	1086	WP_000049106.1	hypothetical protein	-
I6K90_RS11195	2322683..2323072	-	390	WP_000607077.1	membrane protein	Toxin
I6K90_RS11200	2323079..2323336	-	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
I6K90_RS11205	2323524..2324696	+	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
I6K90_RS11210	2324745..2326235	-	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
I6K90_RS11215	2326417..2326794	-	378	WP_001216380.1	50S ribosomal protein L17	-
I6K90_RS11220	2326813..2327820	-	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T191874 WP_000607077.1 NZ_CP069840:c2323072-2322683 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T191874 NZ_CP091977:2650562-2650939 [Aromatoleum aromaticum]
ATGGCCGACAAAGAAAAACCGCTCGAATGGATCGCGAGTAGCTACAAGGATCTGATGGCGTTGCCGCCCGATGTCCGCCG
GCGTTTCGGTTACGCGCTGTCGCTGGCACAGATGGGCGACCAGGACGATGCGGCAAAGGTGCTCAAGGGCTTCGGTGGTG
CCGGCGTGCTGGAGGTCGTCGAAGACGATGCCGGCGGCACGTATCGAGCGGTCTACACGGTCAAGTTCGCGGAAGCGGTG
TTCGTCCTGCACTGCTTCCAGAAGAAGAGCAAGAGCGGGATCGCCACGCCGAAGGCAGACATGGACATCATCCGCTCTCG
GCTGAAGGTGGCCGAGGCAATGGCACAGGAGCTACGAAATGCAAAAACGAATCATTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT191874 WP_001288210.1 NZ_CP069840:c2323336-2323079 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT191874 NZ_CP091977:2650920-2651255 [Aromatoleum aromaticum]
ATGCAAAAACGAATCATTGAAGGCGTCGAGGTTCAGCGCAGCTCAGGCAACGTCTTCGCCGACCTTGGACTGCCGGACGC
CGAGAAACTGAAGATCAAGACCGGCCTGGTGGTCGAGATCAGGAAGGCGATACGTGCTCTTGGGCTGACGCAACAAGCGG
CGGCCAAGCGCATGGGCATCCCGCAACCGAAGGTGTCGGGCATGATGCGTGGCGACTTCACCAACCTGTCCGAGCGCAAG
CTGATGGATTGTCTGAATCGCCTCGGCTACGACATCGAAATCAAGGTACGGCCAGCGTCCGAGCCGGTCGGGCATCTGAC
GCTTGCAACCACCTGA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7